LOW-DOSE INSULIN INFUSIONS IN DIABETIC PATIENTS WITH HIGH INSULIN REQUIREMENTS

P. Dandona; F. Healey; M. Foster; E. Greenbury; A. G. Beckett

doi:10.1016/S0140-6736(78)91688-4

LOW-DOSE INSULIN INFUSIONS IN DIABETIC PATIENTS WITH HIGH INSULIN REQUIREMENTS

P. Dandona
, F. Healey
, M. Foster
, E. Greenbury
, A. G. Beckett

Medicine

University at Buffalo

Royal Free London NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Six patients with high insulin requirements (range 120-3000 units daily) have been infused with much smaller doses (range 50-63 units daily) of insulin intravenously. All six maintained adequate glucose homœostasis on this regimen. It is suggested that subcutaneous tissue at the site of injection may alter insulin or impair its absorption. Insulin resistance in some patients may be due to these mechanisms.

Original language	English
Pages (from-to)	283-285
Number of pages	3
Journal	The Lancet
Volume	312
Issue number	8084
DOIs	https://doi.org/10.1016/S0140-6736(78)91688-4
State	Published - Aug 5 1978

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title = "LOW-DOSE INSULIN INFUSIONS IN DIABETIC PATIENTS WITH HIGH INSULIN REQUIREMENTS",

abstract = "Six patients with high insulin requirements (range 120-3000 units daily) have been infused with much smaller doses (range 50-63 units daily) of insulin intravenously. All six maintained adequate glucose hom{\oe}ostasis on this regimen. It is suggested that subcutaneous tissue at the site of injection may alter insulin or impair its absorption. Insulin resistance in some patients may be due to these mechanisms.",

author = "P. Dandona and F. Healey and M. Foster and E. Greenbury and Beckett, \{A. G.\}",

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AU - Dandona, P.

AU - Healey, F.

AU - Foster, M.

AU - Greenbury, E.

AU - Beckett, A. G.

PY - 1978/8/5

Y1 - 1978/8/5

N2 - Six patients with high insulin requirements (range 120-3000 units daily) have been infused with much smaller doses (range 50-63 units daily) of insulin intravenously. All six maintained adequate glucose homœostasis on this regimen. It is suggested that subcutaneous tissue at the site of injection may alter insulin or impair its absorption. Insulin resistance in some patients may be due to these mechanisms.

AB - Six patients with high insulin requirements (range 120-3000 units daily) have been infused with much smaller doses (range 50-63 units daily) of insulin intravenously. All six maintained adequate glucose homœostasis on this regimen. It is suggested that subcutaneous tissue at the site of injection may alter insulin or impair its absorption. Insulin resistance in some patients may be due to these mechanisms.

UR - https://www.scopus.com/pages/publications/0018261228

U2 - 10.1016/S0140-6736(78)91688-4

DO - 10.1016/S0140-6736(78)91688-4

M3 - Article

C2 - 79081

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VL - 312

SP - 283

EP - 285

JO - The Lancet

JF - The Lancet

IS - 8084

ER -

LOW-DOSE INSULIN INFUSIONS IN DIABETIC PATIENTS WITH HIGH INSULIN REQUIREMENTS

Abstract

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