Magnetic fields associated with anoxic depolarization in anesthetized rats

Y. Takanashi; M. Chopp; S. R. Levine; J. Kim; J. E. Moran; N. Tepley; Q. Chen; G. L. Barkley; K. M.A. Welch

doi:10.1016/0006-8993(91)91180-9

Magnetic fields associated with anoxic depolarization in anesthetized rats

Y. Takanashi
, M. Chopp
, S. R. Levine
, J. Kim
, J. E. Moran
, N. Tepley
, Q. Chen
, G. L. Barkley
, K. M.A. Welch

Neurology

SUNY Downstate Health Sciences University

Henry Ford Health System
Oakland University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We have performed simultaneous measurements of the DC-magnetoencephalogram (DC-MEG) and DC-electrocorticogram (DC-ECoG) in rats (n = 6) subjected to 90 s of reversible anoxia. The onset of major shifts of electric and magnetic signals occurred at 52 ± 18 (S.D.) and 68 ± 14 (S.D.), respectively, and reached a peak at 83 ± 27 and 102 ± 19 (S.D.) s, respectively, after termination of mechanical ventilation. DC-ECoG signal deflections were always associated with DC-MEG deflections. The time of onset and peak signals in both DC-MEG and DC-ECoG changes caused by asphyxia were highly correlated (r + 0.83, 0.94; P < 0.05, 0.001; respectively). Our observations suggest that the non-invasive technique of DC-MEG is reliable and may provide insight into the mechanisms of anoxic cerebral depolarization.

Original language	English
Pages (from-to)	13-16
Number of pages	4
Journal	Brain Research
Volume	562
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(91)91180-9
State	Published - Oct 18 1991

Keywords

Anoxic depolarization
Asphyxia
Electrocorticography
Magnetoencephalography
Neuromagnetism

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10.1016/0006-8993(91)91180-9

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title = "Magnetic fields associated with anoxic depolarization in anesthetized rats",

abstract = "We have performed simultaneous measurements of the DC-magnetoencephalogram (DC-MEG) and DC-electrocorticogram (DC-ECoG) in rats (n = 6) subjected to 90 s of reversible anoxia. The onset of major shifts of electric and magnetic signals occurred at 52 ± 18 (S.D.) and 68 ± 14 (S.D.), respectively, and reached a peak at 83 ± 27 and 102 ± 19 (S.D.) s, respectively, after termination of mechanical ventilation. DC-ECoG signal deflections were always associated with DC-MEG deflections. The time of onset and peak signals in both DC-MEG and DC-ECoG changes caused by asphyxia were highly correlated (r + 0.83, 0.94; P < 0.05, 0.001; respectively). Our observations suggest that the non-invasive technique of DC-MEG is reliable and may provide insight into the mechanisms of anoxic cerebral depolarization.",

keywords = "Anoxic depolarization, Asphyxia, Electrocorticography, Magnetoencephalography, Neuromagnetism",

author = "Y. Takanashi and M. Chopp and Levine, \{S. R.\} and J. Kim and Moran, \{J. E.\} and N. Tepley and Q. Chen and Barkley, \{G. L.\} and Welch, \{K. M.A.\}",

year = "1991",

month = oct,

day = "18",

doi = "10.1016/0006-8993(91)91180-9",

language = "English",

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T1 - Magnetic fields associated with anoxic depolarization in anesthetized rats

AU - Takanashi, Y.

AU - Chopp, M.

AU - Levine, S. R.

AU - Kim, J.

AU - Moran, J. E.

AU - Tepley, N.

AU - Chen, Q.

AU - Barkley, G. L.

AU - Welch, K. M.A.

PY - 1991/10/18

Y1 - 1991/10/18

N2 - We have performed simultaneous measurements of the DC-magnetoencephalogram (DC-MEG) and DC-electrocorticogram (DC-ECoG) in rats (n = 6) subjected to 90 s of reversible anoxia. The onset of major shifts of electric and magnetic signals occurred at 52 ± 18 (S.D.) and 68 ± 14 (S.D.), respectively, and reached a peak at 83 ± 27 and 102 ± 19 (S.D.) s, respectively, after termination of mechanical ventilation. DC-ECoG signal deflections were always associated with DC-MEG deflections. The time of onset and peak signals in both DC-MEG and DC-ECoG changes caused by asphyxia were highly correlated (r + 0.83, 0.94; P < 0.05, 0.001; respectively). Our observations suggest that the non-invasive technique of DC-MEG is reliable and may provide insight into the mechanisms of anoxic cerebral depolarization.

AB - We have performed simultaneous measurements of the DC-magnetoencephalogram (DC-MEG) and DC-electrocorticogram (DC-ECoG) in rats (n = 6) subjected to 90 s of reversible anoxia. The onset of major shifts of electric and magnetic signals occurred at 52 ± 18 (S.D.) and 68 ± 14 (S.D.), respectively, and reached a peak at 83 ± 27 and 102 ± 19 (S.D.) s, respectively, after termination of mechanical ventilation. DC-ECoG signal deflections were always associated with DC-MEG deflections. The time of onset and peak signals in both DC-MEG and DC-ECoG changes caused by asphyxia were highly correlated (r + 0.83, 0.94; P < 0.05, 0.001; respectively). Our observations suggest that the non-invasive technique of DC-MEG is reliable and may provide insight into the mechanisms of anoxic cerebral depolarization.

KW - Anoxic depolarization

KW - Asphyxia

KW - Electrocorticography

KW - Magnetoencephalography

KW - Neuromagnetism

UR - https://www.scopus.com/pages/publications/0026091929

U2 - 10.1016/0006-8993(91)91180-9

DO - 10.1016/0006-8993(91)91180-9

M3 - Article

C2 - 1799865

SN - 0006-8993

VL - 562

SP - 13

EP - 16

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Magnetic fields associated with anoxic depolarization in anesthetized rats

Abstract

Keywords

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