Making the cut: The chemical biology of cytokinesis

G. Ekin Atilla-Gokcumen; Adam B. Castoreno; Sofia Sasse; Ulrike S. Eggert

doi:10.1021/cb900256m

Making the cut: The chemical biology of cytokinesis

G. Ekin Atilla-Gokcumen
, Adam B. Castoreno
, Sofia Sasse
, Ulrike S. Eggert

Chemistry

University at Buffalo

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Cytokinesis is the last step in the cell cycle, where daughter cells finally separate. It is precisely regulated in both time and space to ensure that each daughter cell receives an equal share of DNA and other cellular materials. Chemical biology approaches have been used very successfully to study the mechanism of cytokinesis. In this review, we discuss the use of small molecule probes to perturb cytokinesis, as well as the role naturally occurring small molecule metabolites such as lipids play during cytokinesis.

Original language	English
Pages (from-to)	79-90
Number of pages	12
Journal	ACS Chemical Biology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1021/cb900256m
State	Published - Jan 15 2010

Keywords

Actin
Cleavage furrow/contractile ring
Cytokinesis
Metabolites
Midzone
Myosin
Phosphatidylinositol 4,5-bisphosphate (PIP2)
Small molecule probes
Tubulin

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10.1021/cb900256m

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title = "Making the cut: The chemical biology of cytokinesis",

abstract = "Cytokinesis is the last step in the cell cycle, where daughter cells finally separate. It is precisely regulated in both time and space to ensure that each daughter cell receives an equal share of DNA and other cellular materials. Chemical biology approaches have been used very successfully to study the mechanism of cytokinesis. In this review, we discuss the use of small molecule probes to perturb cytokinesis, as well as the role naturally occurring small molecule metabolites such as lipids play during cytokinesis.",

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T2 - The chemical biology of cytokinesis

AU - Atilla-Gokcumen, G. Ekin

AU - Castoreno, Adam B.

AU - Sasse, Sofia

AU - Eggert, Ulrike S.

PY - 2010/1/15

Y1 - 2010/1/15

N2 - Cytokinesis is the last step in the cell cycle, where daughter cells finally separate. It is precisely regulated in both time and space to ensure that each daughter cell receives an equal share of DNA and other cellular materials. Chemical biology approaches have been used very successfully to study the mechanism of cytokinesis. In this review, we discuss the use of small molecule probes to perturb cytokinesis, as well as the role naturally occurring small molecule metabolites such as lipids play during cytokinesis.

AB - Cytokinesis is the last step in the cell cycle, where daughter cells finally separate. It is precisely regulated in both time and space to ensure that each daughter cell receives an equal share of DNA and other cellular materials. Chemical biology approaches have been used very successfully to study the mechanism of cytokinesis. In this review, we discuss the use of small molecule probes to perturb cytokinesis, as well as the role naturally occurring small molecule metabolites such as lipids play during cytokinesis.

KW - Actin

KW - Cleavage furrow/contractile ring

KW - Cytokinesis

KW - Metabolites

KW - Midzone

KW - Myosin

KW - Phosphatidylinositol 4,5-bisphosphate (PIP2)

KW - Small molecule probes

KW - Tubulin

UR - https://www.scopus.com/pages/publications/75749094423

U2 - 10.1021/cb900256m

DO - 10.1021/cb900256m

M3 - Review article

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SN - 1554-8929

VL - 5

SP - 79

EP - 90

JO - ACS Chemical Biology

JF - ACS Chemical Biology

IS - 1

ER -

Making the cut: The chemical biology of cytokinesis

Abstract

Keywords

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