Malaria surveillance in the Democratic Republic of the Congo: Comparison of microscopy, PCR, and rapid diagnostic test

Stephanie M. Doctor; Yunhao Liu; Amy Whitesell; Kyaw L. Thwai; Steve M. Taylor; Mark Janko; Michael Emch; Melchior Kashamuka; Jérémie Muwonga; Antoinette Tshefu; Steven R. Meshnick

doi:10.1016/j.diagmicrobio.2016.01.004

Malaria surveillance in the Democratic Republic of the Congo: Comparison of microscopy, PCR, and rapid diagnostic test

Stephanie M. Doctor
, Yunhao Liu
, Amy Whitesell
, Kyaw L. Thwai
, Steve M. Taylor
, Mark Janko
, Michael Emch
, Melchior Kashamuka
, Jérémie Muwonga
, Antoinette Tshefu
, Steven R. Meshnick

Department of Epidemiology and Environmental Health

University at Buffalo

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Malaria surveillance is critical for control efforts, but diagnostic methods frequently disagree. Here, we compare microscopy, PCR, and a rapid diagnostic test in 7137 samples from children in the Democratic Republic of the Congo using latent class analysis. PCR had the highest sensitivity (94.6%) and microscopy had the lowest (76.7%).

Original language	English
Pages (from-to)	16-18
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/j.diagmicrobio.2016.01.004
State	Published - May 1 2016

Keywords

Diagnostics
Latent class analysis
Malaria
Microscopy
PCR
RDT
Rapid diagnostic test
Surveillance

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10.1016/j.diagmicrobio.2016.01.004

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Doctor, S. M., Liu, Y., Whitesell, A., Thwai, K. L., Taylor, S. M., Janko, M., Emch, M., Kashamuka, M., Muwonga, J., Tshefu, A., & Meshnick, S. R. (2016). Malaria surveillance in the Democratic Republic of the Congo: Comparison of microscopy, PCR, and rapid diagnostic test. Diagnostic Microbiology and Infectious Disease, 85(1), 16-18. https://doi.org/10.1016/j.diagmicrobio.2016.01.004

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abstract = "Malaria surveillance is critical for control efforts, but diagnostic methods frequently disagree. Here, we compare microscopy, PCR, and a rapid diagnostic test in 7137 samples from children in the Democratic Republic of the Congo using latent class analysis. PCR had the highest sensitivity (94.6\%) and microscopy had the lowest (76.7\%).",

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doi = "10.1016/j.diagmicrobio.2016.01.004",

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Doctor, SM, Liu, Y, Whitesell, A, Thwai, KL, Taylor, SM, Janko, M, Emch, M, Kashamuka, M, Muwonga, J, Tshefu, A & Meshnick, SR 2016, 'Malaria surveillance in the Democratic Republic of the Congo: Comparison of microscopy, PCR, and rapid diagnostic test', Diagnostic Microbiology and Infectious Disease, vol. 85, no. 1, pp. 16-18. https://doi.org/10.1016/j.diagmicrobio.2016.01.004

TY - JOUR

T1 - Malaria surveillance in the Democratic Republic of the Congo

T2 - Comparison of microscopy, PCR, and rapid diagnostic test

AU - Doctor, Stephanie M.

AU - Liu, Yunhao

AU - Whitesell, Amy

AU - Thwai, Kyaw L.

AU - Taylor, Steve M.

AU - Janko, Mark

AU - Emch, Michael

AU - Kashamuka, Melchior

AU - Muwonga, Jérémie

AU - Tshefu, Antoinette

AU - Meshnick, Steven R.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Malaria surveillance is critical for control efforts, but diagnostic methods frequently disagree. Here, we compare microscopy, PCR, and a rapid diagnostic test in 7137 samples from children in the Democratic Republic of the Congo using latent class analysis. PCR had the highest sensitivity (94.6%) and microscopy had the lowest (76.7%).

AB - Malaria surveillance is critical for control efforts, but diagnostic methods frequently disagree. Here, we compare microscopy, PCR, and a rapid diagnostic test in 7137 samples from children in the Democratic Republic of the Congo using latent class analysis. PCR had the highest sensitivity (94.6%) and microscopy had the lowest (76.7%).

KW - Diagnostics

KW - Latent class analysis

KW - Malaria

KW - Microscopy

KW - PCR

KW - RDT

KW - Rapid diagnostic test

KW - Surveillance

UR - https://www.scopus.com/pages/publications/84963622366

U2 - 10.1016/j.diagmicrobio.2016.01.004

DO - 10.1016/j.diagmicrobio.2016.01.004

M3 - Article

C2 - 26915637

SN - 0732-8893

VL - 85

SP - 16

EP - 18

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 1

ER -

Malaria surveillance in the Democratic Republic of the Congo: Comparison of microscopy, PCR, and rapid diagnostic test

Abstract

Keywords

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