Abstract
Precocious puberty has been a focus of interest for both the pediatric endocrinologist and the primary pediatrician for many years. The development and application of gonadotropin-releasing hormone (GnRH) agonist (GnRHa) therapy to treat central precocious puberty in the 1980s significantly changed our approach to this disorder. More recently, application of molecular biological techniques has led to a better understanding of the intricacies of regulation of gonadotropin and sex-steroid production characteristic of normal pubertal development and provided us with the tools to elucidate etiologies of previously uncharacterized disorders of precocious puberty.
| Original language | English |
|---|---|
| Title of host publication | Pediatric Endocrinology |
| Subtitle of host publication | A Practical Clinical Guide, Fourth Edition |
| Publisher | Springer Nature |
| Pages | 721-746 |
| Number of pages | 26 |
| ISBN (Electronic) | 9783031662966 |
| ISBN (Print) | 9783031662959 |
| DOIs | |
| State | Published - Jan 1 2024 |
Keywords
- Clitoral surgery
- DSD and parental reaction
- DSD and quality of life
- Disorders of sex development/differences of sex development
- Gender change
- Gender dysphoria
- Legal issues globally
- Medical management of DSD
- Non-categorical
- Shared decision making
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