Mathematical model of the transport of macromolecules and recycling of their membrane receptors in the cell

V. A. Kuznetsov; L. R. Alekhina

Mathematical model of the transport of macromolecules and recycling of their membrane receptors in the cell

V. A. Kuznetsov
, L. R. Alekhina

Urology

Upstate Medical University

Russian Academy of Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A mathematical model is proposed for analysing the dynamics of receptor-mediated endocytosis of bivalent macromolecules and recycling in the cell of the corresponding receptors. The conditions allowing one in kinetic experiments to distinguish receptor-mediated endocytosis of mono- and bivalent ligands are defined. From the results it is concluded that binding of the receptors by a bivalent ligand, the heterogeneity of the receptors and their recycling capacity may form the mechanism regulating the different functions of the cell including proliferation, adhesion and differentiation.

Original language	English
Pages (from-to)	299-304
Number of pages	6
Journal	Biophysics
Volume	35
Issue number	2
State	Published - 1990

Cite this

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title = "Mathematical model of the transport of macromolecules and recycling of their membrane receptors in the cell",

abstract = "A mathematical model is proposed for analysing the dynamics of receptor-mediated endocytosis of bivalent macromolecules and recycling in the cell of the corresponding receptors. The conditions allowing one in kinetic experiments to distinguish receptor-mediated endocytosis of mono- and bivalent ligands are defined. From the results it is concluded that binding of the receptors by a bivalent ligand, the heterogeneity of the receptors and their recycling capacity may form the mechanism regulating the different functions of the cell including proliferation, adhesion and differentiation.",

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AU - Kuznetsov, V. A.

AU - Alekhina, L. R.

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N2 - A mathematical model is proposed for analysing the dynamics of receptor-mediated endocytosis of bivalent macromolecules and recycling in the cell of the corresponding receptors. The conditions allowing one in kinetic experiments to distinguish receptor-mediated endocytosis of mono- and bivalent ligands are defined. From the results it is concluded that binding of the receptors by a bivalent ligand, the heterogeneity of the receptors and their recycling capacity may form the mechanism regulating the different functions of the cell including proliferation, adhesion and differentiation.

AB - A mathematical model is proposed for analysing the dynamics of receptor-mediated endocytosis of bivalent macromolecules and recycling in the cell of the corresponding receptors. The conditions allowing one in kinetic experiments to distinguish receptor-mediated endocytosis of mono- and bivalent ligands are defined. From the results it is concluded that binding of the receptors by a bivalent ligand, the heterogeneity of the receptors and their recycling capacity may form the mechanism regulating the different functions of the cell including proliferation, adhesion and differentiation.

UR - https://www.scopus.com/pages/publications/45149137210

M3 - Article

SN - 0006-3509

VL - 35

SP - 299

EP - 304

JO - Biophysics

JF - Biophysics

IS - 2

ER -

Mathematical model of the transport of macromolecules and recycling of their membrane receptors in the cell

Abstract

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