Methyl pyropheophorbide-a analogues: Potential fluorescent probes for the peripheral-type benzodiazepine receptor. Effect of central metal in photosensitizing efficacy

Yihui Chen; Xiang Zheng; Mahabeer P. Dobhal; Amy Gryshuk; Janet Morgan; Thomas J. Dougherty; Allan Oseroff; Ravindra K. Pandey

doi:10.1021/jm050039k

Methyl pyropheophorbide-a analogues: Potential fluorescent probes for the peripheral-type benzodiazepine receptor. Effect of central metal in photosensitizing efficacy

Yihui Chen
, Xiang Zheng
, Mahabeer P. Dobhal
, Amy Gryshuk
, Janet Morgan
, Thomas J. Dougherty
, Allan Oseroff
, Ravindra K. Pandey

Institute for Lasers Photonics and Biophotonics

University at Buffalo

Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Pyropheophorbides and their metal complexes were synthesized to investigate their applications as nonradioactive peripheral benzodiazepine receptor (PBR) binding probes and photosensitizers for use in photodynamic therapy. They were found to be localized in mitochondria and showed significant binding to PBR. In some cases, the PBR binding values were similar to that for 17 (PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide). However, no direct correlation between 17 displacement ability and photosensitizing efficacy of photosensitizers was observed.

Original language	English
Pages (from-to)	3692-3695
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	48
Issue number	11
DOIs	https://doi.org/10.1021/jm050039k
State	Published - Jun 2 2005

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10.1021/jm050039k

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@article{16a1eff741464c819e24c8b1baa7b706,

title = "Methyl pyropheophorbide-a analogues: Potential fluorescent probes for the peripheral-type benzodiazepine receptor. Effect of central metal in photosensitizing efficacy",

abstract = "Pyropheophorbides and their metal complexes were synthesized to investigate their applications as nonradioactive peripheral benzodiazepine receptor (PBR) binding probes and photosensitizers for use in photodynamic therapy. They were found to be localized in mitochondria and showed significant binding to PBR. In some cases, the PBR binding values were similar to that for 17 (PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide). However, no direct correlation between 17 displacement ability and photosensitizing efficacy of photosensitizers was observed.",

author = "Yihui Chen and Xiang Zheng and Dobhal, \{Mahabeer P.\} and Amy Gryshuk and Janet Morgan and Dougherty, \{Thomas J.\} and Allan Oseroff and Pandey, \{Ravindra K.\}",

year = "2005",

month = jun,

day = "2",

doi = "10.1021/jm050039k",

language = "English",

volume = "48",

pages = "3692--3695",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "11",

}

Methyl pyropheophorbide-a analogues: Potential fluorescent probes for the peripheral-type benzodiazepine receptor. Effect of central metal in photosensitizing efficacy. / Chen, Yihui; Zheng, Xiang; Dobhal, Mahabeer P. et al.
In: Journal of Medicinal Chemistry, Vol. 48, No. 11, 02.06.2005, p. 3692-3695.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Methyl pyropheophorbide-a analogues

T2 - Potential fluorescent probes for the peripheral-type benzodiazepine receptor. Effect of central metal in photosensitizing efficacy

AU - Chen, Yihui

AU - Zheng, Xiang

AU - Dobhal, Mahabeer P.

AU - Gryshuk, Amy

AU - Morgan, Janet

AU - Dougherty, Thomas J.

AU - Oseroff, Allan

AU - Pandey, Ravindra K.

PY - 2005/6/2

Y1 - 2005/6/2

N2 - Pyropheophorbides and their metal complexes were synthesized to investigate their applications as nonradioactive peripheral benzodiazepine receptor (PBR) binding probes and photosensitizers for use in photodynamic therapy. They were found to be localized in mitochondria and showed significant binding to PBR. In some cases, the PBR binding values were similar to that for 17 (PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide). However, no direct correlation between 17 displacement ability and photosensitizing efficacy of photosensitizers was observed.

AB - Pyropheophorbides and their metal complexes were synthesized to investigate their applications as nonradioactive peripheral benzodiazepine receptor (PBR) binding probes and photosensitizers for use in photodynamic therapy. They were found to be localized in mitochondria and showed significant binding to PBR. In some cases, the PBR binding values were similar to that for 17 (PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide). However, no direct correlation between 17 displacement ability and photosensitizing efficacy of photosensitizers was observed.

UR - https://www.scopus.com/pages/publications/20144378663

U2 - 10.1021/jm050039k

DO - 10.1021/jm050039k

M3 - Article

C2 - 15916419

SN - 0022-2623

VL - 48

SP - 3692

EP - 3695

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 11

ER -

Methyl pyropheophorbide-a analogues: Potential fluorescent probes for the peripheral-type benzodiazepine receptor. Effect of central metal in photosensitizing efficacy

Abstract

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