Abstract
Identifying novel mechanisms contributing to patient variability of drug response is a major goal of personalized medicine. Epigenetic regulation of gene expression by microRNA (miRNA) impacts a broad range of cellular processes, but knowledge of its regulation of drug-metabolizing enzymes (DMEs) is more limited. This review provides an introduction to miRNA and their functionality and summarizes known miRNA regulation of DME families, including the cytochrome P450s, UDP-glucuronoslytransferases, glutathione-S-transferases, sulfotransferases and aldo-keto reductases, and the transcription factors known to be involved in DME regulation.
| Original language | English |
|---|---|
| Pages (from-to) | 320-334 |
| Number of pages | 15 |
| Journal | Drug Metabolism Reviews |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 3 2015 |
Keywords
- epigenetic regulation
- metabolizing enzymes
- miRNA
- phase I metabolism
- phase II metabolism
- transcription factors
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