MMP-9 microsatellite polymorphism and multiple sclerosis

Nicola Fiotti; Robert Zivadinov; Nicola Altamura; Davide Nasuelli; Alessio Bratina; Maria Antonietta Tommasi; Antonio Bosco; Laura Locatelli; Attilio Grop; Giuseppe Cazzato; Gianfranco Guarnieri; Carlo Giansante; Marino Zorzon

doi:10.1016/j.jneuroim.2004.03.009

MMP-9 microsatellite polymorphism and multiple sclerosis

Nicola Fiotti
, Robert Zivadinov
, Nicola Altamura
, Davide Nasuelli
, Alessio Bratina
, Maria Antonietta Tommasi
, Antonio Bosco
, Laura Locatelli
, Attilio Grop
, Giuseppe Cazzato
, Gianfranco Guarnieri
, Carlo Giansante
, Marino Zorzon

Neurology

University at Buffalo

University of Trieste

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P<0.0001) and prevalence of carriers of ≥22 CA repeats was higher in the MS than in the Control Group (OR 3.4, 95% CI: 1.7-6.8, P<0.0001). An earlier age at disease onset was a characteristic of patients with >22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.

Original language	English
Pages (from-to)	147-153
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	152
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.03.009
State	Published - Jul 2004

Keywords

MMP-9
MRI
Multiple sclerosis

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10.1016/j.jneuroim.2004.03.009

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@article{d04329d8e1bc4d67ba069210047d81a3,

title = "MMP-9 microsatellite polymorphism and multiple sclerosis",

abstract = "A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P<0.0001) and prevalence of carriers of ≥22 CA repeats was higher in the MS than in the Control Group (OR 3.4, 95\% CI: 1.7-6.8, P<0.0001). An earlier age at disease onset was a characteristic of patients with >22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.",

keywords = "MMP-9, MRI, Multiple sclerosis",

author = "Nicola Fiotti and Robert Zivadinov and Nicola Altamura and Davide Nasuelli and Alessio Bratina and Tommasi, \{Maria Antonietta\} and Antonio Bosco and Laura Locatelli and Attilio Grop and Giuseppe Cazzato and Gianfranco Guarnieri and Carlo Giansante and Marino Zorzon",

year = "2004",

month = jul,

doi = "10.1016/j.jneuroim.2004.03.009",

language = "English",

volume = "152",

pages = "147--153",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

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}

TY - JOUR

T1 - MMP-9 microsatellite polymorphism and multiple sclerosis

AU - Fiotti, Nicola

AU - Zivadinov, Robert

AU - Altamura, Nicola

AU - Nasuelli, Davide

AU - Bratina, Alessio

AU - Tommasi, Maria Antonietta

AU - Bosco, Antonio

AU - Locatelli, Laura

AU - Grop, Attilio

AU - Cazzato, Giuseppe

AU - Guarnieri, Gianfranco

AU - Giansante, Carlo

AU - Zorzon, Marino

PY - 2004/7

Y1 - 2004/7

N2 - A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P<0.0001) and prevalence of carriers of ≥22 CA repeats was higher in the MS than in the Control Group (OR 3.4, 95% CI: 1.7-6.8, P<0.0001). An earlier age at disease onset was a characteristic of patients with >22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.

AB - A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P<0.0001) and prevalence of carriers of ≥22 CA repeats was higher in the MS than in the Control Group (OR 3.4, 95% CI: 1.7-6.8, P<0.0001). An earlier age at disease onset was a characteristic of patients with >22 CA repeats (33±10 vs. 28±10, P=0.027). No differences were found in the main MRI parameters.

KW - MMP-9

KW - MRI

KW - Multiple sclerosis

UR - https://www.scopus.com/pages/publications/3042610060

U2 - 10.1016/j.jneuroim.2004.03.009

DO - 10.1016/j.jneuroim.2004.03.009

M3 - Article

C2 - 15223247

SN - 0165-5728

VL - 152

SP - 147

EP - 153

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

MMP-9 microsatellite polymorphism and multiple sclerosis

Abstract

Keywords

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