@inbook{bc9981b8a1ca4bd2ab5b2dabbdfcb1d6,
title = "Model phospholipid liposomes to study the β-amyloid-peptide-induced membrane disruption",
abstract = "Model phospholipid liposomes have been utilized widely to study the molecular interactions between peptides and membrane bilayers. In the mechanistic study of Alzheimer{\textquoteright}s disease (AD), disruption of neuronal cell membranes has been considered as a major contribution for the β-amyloid (Aβ) peptides{\textquoteright} neurotoxicity. However, clear interpretation of the Aβ-induced cellular membrane at high-resolution level is challenging because of the co-existence of multiple pathways. Here we present the generation of simplified model liposome systems that will facilitate the in-depth mechanistic studies. Protocols for the preparation of model liposomes and the characterization of individual membrane disruption effects will be described.",
keywords = "Electrophysiology, Fibrillation, Ion channels, Membrane disruption, Phospholipid liposomes, lipid mixing, β-Amyloid peptides",
author = "Wei Qiang and Doherty, \{Katelynne E.\}",
note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2018",
doi = "10.1007/978-1-4939-7811-3\_23",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "355--367",
booktitle = "Methods in Molecular Biology",
}