Modification of nucleoside heterocycles to probe and expand nucleic acid structure and function

Eriks Rozners

doi:10.2174/1570178054640714

Modification of nucleoside heterocycles to probe and expand nucleic acid structure and function

Eriks Rozners

Chemistry

Binghamton University

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Recent progress in molecular biology and genetics has invigorated interest in modified nucleic acids both for fundamental studies and for practical applications. Herein, recent advances in design of modified non-Watson-Crick base pairs are highlighted. Examples of altered hydrogen-bonding patterns, size-expanded bases, and base pairing dependent on metal chelation and hydrophobic interactions are discussed.

Original language	English
Pages (from-to)	496-500
Number of pages	5
Journal	Letters in Organic Chemistry
Volume	2
Issue number	6
DOIs	https://doi.org/10.2174/1570178054640714
State	Published - Sep 2005

Keywords

Epimerization
Heterocyclic bases
Hybridization
Hydrophobic base
Nucleobases
Watson-crick-like hydrogen-bonding
dna

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10.2174/1570178054640714

Cite this

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abstract = "Recent progress in molecular biology and genetics has invigorated interest in modified nucleic acids both for fundamental studies and for practical applications. Herein, recent advances in design of modified non-Watson-Crick base pairs are highlighted. Examples of altered hydrogen-bonding patterns, size-expanded bases, and base pairing dependent on metal chelation and hydrophobic interactions are discussed.",

keywords = "Epimerization, Heterocyclic bases, Hybridization, Hydrophobic base, Nucleobases, Watson-crick-like hydrogen-bonding, dna",

author = "Eriks Rozners",

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AU - Rozners, Eriks

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N2 - Recent progress in molecular biology and genetics has invigorated interest in modified nucleic acids both for fundamental studies and for practical applications. Herein, recent advances in design of modified non-Watson-Crick base pairs are highlighted. Examples of altered hydrogen-bonding patterns, size-expanded bases, and base pairing dependent on metal chelation and hydrophobic interactions are discussed.

AB - Recent progress in molecular biology and genetics has invigorated interest in modified nucleic acids both for fundamental studies and for practical applications. Herein, recent advances in design of modified non-Watson-Crick base pairs are highlighted. Examples of altered hydrogen-bonding patterns, size-expanded bases, and base pairing dependent on metal chelation and hydrophobic interactions are discussed.

KW - Epimerization

KW - Heterocyclic bases

KW - Hybridization

KW - Hydrophobic base

KW - Nucleobases

KW - Watson-crick-like hydrogen-bonding

KW - dna

UR - https://www.scopus.com/pages/publications/38949130258

U2 - 10.2174/1570178054640714

DO - 10.2174/1570178054640714

M3 - Review article

SN - 1570-1786

VL - 2

SP - 496

EP - 500

JO - Letters in Organic Chemistry

JF - Letters in Organic Chemistry

IS - 6

ER -

Modification of nucleoside heterocycles to probe and expand nucleic acid structure and function

Abstract

Keywords

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