Modulation of human peripheral blood eosinophil function by tumor necrosis factor-alpha

Eosinophils are important effectors in helminthic parasitic infection. Tumor necrosis factor (TNF-α) has been implicated as a mediator in the host response to parasitic infection and enhances eosinophil-mediated helminthotoxicity. We have examined the direct effects of recombinant human (rh)TNF-α on eosinophil functions of degranulation and oxidative metabolism. This report describes the minimal effects of rhTNF-a on eosinophil superoxide anion generation and enzyme secretion, which do not satisfactorily explain the observed increases in helminthotoxicity. In contrast to other cell types, eosinophils are unique in their differential responses to interleukin-lβ and TNF.