Molecular cloning and characterization of cDNA sequences coding for rat relaxin

P. Hudson; J. Haley; M. Cronk; J. Shine; H. Niall

doi:10.1038/291127a0

Molecular cloning and characterization of cDNA sequences coding for rat relaxin

P. Hudson
, J. Haley
, M. Cronk
, J. Shine
, H. Niall

Pathology

Stony Brook University

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

Using a synthetic oligonucleotide primer, cloned DNA fragments, each containing the entire coding sequence of rat relaxin, have been isolated from a clone 'bank' of ovarian mRNA sequences. The nucleotide sequence of these clones demonstrates that relaxin is synthesized as a preprorelaxin molecule with an unexpectedly large connecting peptide of 105 amino acid residues.

Original language	English
Pages (from-to)	127-131
Number of pages	5
Journal	Nature
Volume	291
Issue number	5811
DOIs	https://doi.org/10.1038/291127a0
State	Published - 1981

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title = "Molecular cloning and characterization of cDNA sequences coding for rat relaxin",

abstract = "Using a synthetic oligonucleotide primer, cloned DNA fragments, each containing the entire coding sequence of rat relaxin, have been isolated from a clone 'bank' of ovarian mRNA sequences. The nucleotide sequence of these clones demonstrates that relaxin is synthesized as a preprorelaxin molecule with an unexpectedly large connecting peptide of 105 amino acid residues.",

author = "P. Hudson and J. Haley and M. Cronk and J. Shine and H. Niall",

year = "1981",

doi = "10.1038/291127a0",

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T1 - Molecular cloning and characterization of cDNA sequences coding for rat relaxin

AU - Hudson, P.

AU - Haley, J.

AU - Cronk, M.

AU - Shine, J.

AU - Niall, H.

PY - 1981

Y1 - 1981

N2 - Using a synthetic oligonucleotide primer, cloned DNA fragments, each containing the entire coding sequence of rat relaxin, have been isolated from a clone 'bank' of ovarian mRNA sequences. The nucleotide sequence of these clones demonstrates that relaxin is synthesized as a preprorelaxin molecule with an unexpectedly large connecting peptide of 105 amino acid residues.

AB - Using a synthetic oligonucleotide primer, cloned DNA fragments, each containing the entire coding sequence of rat relaxin, have been isolated from a clone 'bank' of ovarian mRNA sequences. The nucleotide sequence of these clones demonstrates that relaxin is synthesized as a preprorelaxin molecule with an unexpectedly large connecting peptide of 105 amino acid residues.

UR - https://www.scopus.com/pages/publications/0019452660

U2 - 10.1038/291127a0

DO - 10.1038/291127a0

M3 - Article

C2 - 7231533

SN - 0028-0836

VL - 291

SP - 127

EP - 131

JO - Nature

JF - Nature

IS - 5811

ER -

Molecular cloning and characterization of cDNA sequences coding for rat relaxin

Abstract

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