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Monte Carlo modeling and experimental terahertz polarimetric imaging of tumor budding due to Mie scattering

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Many disease processes, including cancerous tumors and burn injuries, induce changes in the structure of tissue. Polarimetric terahertz measurements have the potential to provide new diagnostic markers using Mie scattering patterns. In this work, we present Monte Carlo simulation of Mie scattering of polarized terahertz light for cancerous tumor budding and compare the results to experimental phantom measurements. Additionally, we present a polarization-sensitive scan of an ex vivo porcine burn injury. The experimental phantom results showed contrast between different sizes of polypropylene scattering particles within a gelatin medium for diffuse intensity and degree of polarization measurements. A similar diffuse imaging signal contrast was demonstrated between burned and healthy regions on ex vivo porcine skin. These results show the potential for polarimetric terahertz imaging in detecting structural changes from disease processes.

Original languageEnglish
Title of host publicationPolarized Light and Optical Angular Momentum for Biomedical Diagnostics 2025
EditorsJessica C. Ramella-Roman, Hui Ma, Tatiana Novikova, Daniel S. Elson, I. Alex Vitkin
PublisherSPIE
ISBN (Electronic)9781510683921
DOIs
StatePublished - 2025
EventPolarized Light and Optical Angular Momentum for Biomedical Diagnostics 2025 - San Francisco, United States
Duration: Jan 25 2025Jan 26 2025

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume13322

Conference

ConferencePolarized Light and Optical Angular Momentum for Biomedical Diagnostics 2025
Country/TerritoryUnited States
CitySan Francisco
Period01/25/2501/26/25

Keywords

  • Diffused scattering
  • Mie scattering
  • THz-TDS
  • Terahertz time-domain spectroscopy and polarimetry
  • Tumor budding
  • degree of polarization (DOP)

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