Abstract
Background: We tested whether insulin cells expressing an inducible RIP-Cre transgene display a normal phenotype. Results: RipCre insulin cells die when the stimulation of insulin synthesis is protracted. Conclusion: Beta cells expressing an inducible RIP-Cre transgene are functionally deficient. Significance: The use of an inducible RIPCre system to examine beta cell gene function/development could distort experimental results.
| Original language | English |
|---|---|
| Pages (from-to) | 3647-3653 |
| Number of pages | 7 |
| Journal | Journal of Biological Chemistry |
| Volume | 290 |
| Issue number | 6 |
| DOIs | |
| State | Published - Feb 6 2015 |
Fingerprint
Dive into the research topics of 'Mouse insulin cells expressing an inducible RIPCre transgene are functionally impaired'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver