Nature and Nurture Converge in the Nucleus to Regulate Activity-Dependent Neuronal Development

Jacqueline R. Thompson; Yingxi Lin

doi:10.1007/978-3-031-68550-7_10

Nature and Nurture Converge in the Nucleus to Regulate Activity-Dependent Neuronal Development

Jacqueline R. Thompson
, Yingxi Lin

Psychiatry

Upstate Medical University

SUNY Upstate Medical University
Johns Hopkins University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Both genetic and environmental factors shape the process of neurodevelopment. At the interface of nature and nurture lies neuronal activity-dependent transcription, which, by internalizing experiences, sculpts and optimizes the primitive neural circuits laid down by a hardwired genetic program. In this chapter, we will review the important roles played by activity-dependent transcription in the key steps of the development of functional neural circuits: neurite development, synapse formation, and synaptic plasticity. We’ll also discuss how activity-dependent transcription is relevant to understanding the mechanisms underlying neurodevelopmental disorders.

Original language	English
Title of host publication	Transcriptional Regulation by Neuronal Activity
Subtitle of host publication	To the Nucleus and Back
Publisher	Springer Nature
Pages	301-347
Number of pages	47
ISBN (Electronic)	9783031685507
ISBN (Print)	9783031685491
DOIs	https://doi.org/10.1007/978-3-031-68550-7_10
State	Published - Jan 1 2024

Keywords

Activity-dependent transcription
Neurite development
Synapse formation
Synaptic plasticity
and Neurodevelopmental disorders

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10.1007/978-3-031-68550-7_10

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AB - Both genetic and environmental factors shape the process of neurodevelopment. At the interface of nature and nurture lies neuronal activity-dependent transcription, which, by internalizing experiences, sculpts and optimizes the primitive neural circuits laid down by a hardwired genetic program. In this chapter, we will review the important roles played by activity-dependent transcription in the key steps of the development of functional neural circuits: neurite development, synapse formation, and synaptic plasticity. We’ll also discuss how activity-dependent transcription is relevant to understanding the mechanisms underlying neurodevelopmental disorders.

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KW - Synapse formation

KW - Synaptic plasticity

KW - and Neurodevelopmental disorders

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PB - Springer Nature

ER -

Nature and Nurture Converge in the Nucleus to Regulate Activity-Dependent Neuronal Development

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Keywords

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