Neural development goes retro: Gags as essential modulators of synapse formation

Yung Heng Chang; Josh Dubnau

doi:10.1371/journal.pbio.3003032

Neural development goes retro: Gags as essential modulators of synapse formation

Yung Heng Chang
, Josh Dubnau

Stony Brook University

Stony Brook University

Research output: Contribution to journal › Article › peer-review

Abstract

Neurodevelopment requires dynamic control of synapse number. A new study in PLOS Biology reveals that the gag protein of Copia, an active retrotransposon, forms virus-like capsids that transfer its own RNA across the Drosophila neuromuscular junction. Here, Copia acts antagonistically with Arc, another retrotransposon gag protein, to regulate synapse formation.

Original language	English
Article number	e3003032
Journal	PLOS Biology
Volume	23
Issue number	2 February
DOIs	https://doi.org/10.1371/journal.pbio.3003032
State	Published - Feb 2025

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10.1371/journal.pbio.3003032

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abstract = "Neurodevelopment requires dynamic control of synapse number. A new study in PLOS Biology reveals that the gag protein of Copia, an active retrotransposon, forms virus-like capsids that transfer its own RNA across the Drosophila neuromuscular junction. Here, Copia acts antagonistically with Arc, another retrotransposon gag protein, to regulate synapse formation.",

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Neural development goes retro: Gags as essential modulators of synapse formation

Abstract

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