Neurodegenerative hospital admissions and long-term exposure to ambient fine particle air pollution

Purpose: Long-term exposure to ambient fine particle (PM_2.5) concentrations has been associated with an increased rate or risk of neurodegenerative conditions, but individual PM sources have not been previously examined in relation to neurodegenerative diseases. Methods: Using the Statewide Planning and Research Cooperative System database, we studied 63,287 hospital admissions with a primary diagnosis of either Alzheimer's disease, dementia, or Parkinson's disease for New York State residents living within 15 miles from six PM_2.5 monitoring sites. In addition to PM_2.5 concentrations, we studied seven specific PM_2.5 sources: secondary sulfate, secondary nitrate, biomass burning, diesel, spark-ignition emissions, pyrolyzed organic rich, and road dust. We estimated the rate of neurodegenerative hospital admissions associated with increased concentration of PM_2.5 and individual PM_2.5 sources average concentrations in the previous 0–29, 0–179, and 0–364 days. Results: Increases in ambient PM_2.5 concentrations were not consistently associated with increased hospital admissions rates. Increased source-specific PM2.5 concentrations were associated with both increased (e.g., secondary sulfates and diesel emissions) and decreased rates (e.g., secondary nitrate and spark-ignition vehicular emissions) of neurodegenerative admissions. Conclusions: We did not observe clear associations between overall ambient PM_2.5 concentrations or source-apportioned ambient PM_2.5 contributions and rates of neurologic disease hospitalizations.