Neuroleptic binding and their effects on the spontaneous and potassium-evoked release of 3H-dopamine from the striatum and of 3H-noradrenaline from the cerebral cortex

S. Arbilla; M. S. Briley; M. L. Dubocovich; S. Z. Langer

doi:10.1016/0024-3205(78)90107-8

Neuroleptic binding and their effects on the spontaneous and potassium-evoked release of ³H-dopamine from the striatum and of ³H-noradrenaline from the cerebral cortex

S. Arbilla
, M. S. Briley
, M. L. Dubocovich
, S. Z. Langer

Pharmacology and Toxicology

University at Buffalo

Sanofi-Aventis

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Neither dopamine agonists nor neuroleptics modified the stimulation-evoked release of ³H-dopamine from rat striatal slices. In contrast the stimulation-evoked release of ³H-noradrenaline from slices of rat occipital cortex was enhanced by neuroleptics through a blockade of presynaptic α-adrenoceptors. ³H-neuroleptic binding shows two binding sites in both rat striatum and cortex.

Original language	English
Pages (from-to)	1775-1780
Number of pages	6
Journal	Life Sciences
Volume	23
Issue number	17-18
DOIs	https://doi.org/10.1016/0024-3205(78)90107-8
State	Published - Oct 30 1978

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title = "Neuroleptic binding and their effects on the spontaneous and potassium-evoked release of 3H-dopamine from the striatum and of 3H-noradrenaline from the cerebral cortex",

abstract = "Neither dopamine agonists nor neuroleptics modified the stimulation-evoked release of 3H-dopamine from rat striatal slices. In contrast the stimulation-evoked release of 3H-noradrenaline from slices of rat occipital cortex was enhanced by neuroleptics through a blockade of presynaptic α-adrenoceptors. 3H-neuroleptic binding shows two binding sites in both rat striatum and cortex.",

author = "S. Arbilla and Briley, \{M. S.\} and Dubocovich, \{M. L.\} and Langer, \{S. Z.\}",

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T1 - Neuroleptic binding and their effects on the spontaneous and potassium-evoked release of 3H-dopamine from the striatum and of 3H-noradrenaline from the cerebral cortex

AU - Arbilla, S.

AU - Briley, M. S.

AU - Dubocovich, M. L.

AU - Langer, S. Z.

PY - 1978/10/30

Y1 - 1978/10/30

N2 - Neither dopamine agonists nor neuroleptics modified the stimulation-evoked release of 3H-dopamine from rat striatal slices. In contrast the stimulation-evoked release of 3H-noradrenaline from slices of rat occipital cortex was enhanced by neuroleptics through a blockade of presynaptic α-adrenoceptors. 3H-neuroleptic binding shows two binding sites in both rat striatum and cortex.

AB - Neither dopamine agonists nor neuroleptics modified the stimulation-evoked release of 3H-dopamine from rat striatal slices. In contrast the stimulation-evoked release of 3H-noradrenaline from slices of rat occipital cortex was enhanced by neuroleptics through a blockade of presynaptic α-adrenoceptors. 3H-neuroleptic binding shows two binding sites in both rat striatum and cortex.

UR - https://www.scopus.com/pages/publications/0018114113

U2 - 10.1016/0024-3205(78)90107-8

DO - 10.1016/0024-3205(78)90107-8

M3 - Article

C2 - 31532

SN - 0024-3205

VL - 23

SP - 1775

EP - 1780

JO - Life Sciences

JF - Life Sciences

IS - 17-18

ER -

Neuroleptic binding and their effects on the spontaneous and potassium-evoked release of ³H-dopamine from the striatum and of ³H-noradrenaline from the cerebral cortex

Abstract

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