New insights into drug resistance in cancer

Iwao Ojima; Cristiano Ferlini

doi:10.1016/S1074-5521(03)00152-2

New insights into drug resistance in cancer

Iwao Ojima
, Cristiano Ferlini

Chemistry

Stony Brook University

Catholic University of the Sacred Heart

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

New findings by Kavallaris et al. characterize mechanisms of resistance to epothilones and paclitaxel in cell lines. One significant discovery is a novel tubulin point mutation positioned outside the paclitaxel binding site, which confers a high degree of drug resistance.

Original language	English
Pages (from-to)	583-584
Number of pages	2
Journal	Chemistry and Biology
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/S1074-5521(03)00152-2
State	Published - Jul 1 2003

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10.1016/S1074-5521(03)00152-2

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title = "New insights into drug resistance in cancer",

abstract = "New findings by Kavallaris et al. characterize mechanisms of resistance to epothilones and paclitaxel in cell lines. One significant discovery is a novel tubulin point mutation positioned outside the paclitaxel binding site, which confers a high degree of drug resistance.",

author = "Iwao Ojima and Cristiano Ferlini",

year = "2003",

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AU - Ojima, Iwao

AU - Ferlini, Cristiano

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AB - New findings by Kavallaris et al. characterize mechanisms of resistance to epothilones and paclitaxel in cell lines. One significant discovery is a novel tubulin point mutation positioned outside the paclitaxel binding site, which confers a high degree of drug resistance.

UR - https://www.scopus.com/pages/publications/0042631316

U2 - 10.1016/S1074-5521(03)00152-2

DO - 10.1016/S1074-5521(03)00152-2

M3 - Review article

SN - 1074-5521

VL - 10

SP - 583

EP - 584

JO - Chemistry and Biology

JF - Chemistry and Biology

IS - 7

ER -

New insights into drug resistance in cancer

Abstract

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