Nitric oxide and multiple sclerosis

Juan Manuel Encinas; Louis Manganas; Grigori Enikolopov

doi:10.1007/s11910-005-0051-y

Nitric oxide and multiple sclerosis

Juan Manuel Encinas
, Louis Manganas
, Grigori Enikolopov

Anesthesiology

Stony Brook University

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

Nitric oxide (NO) is a free radical signaling molecule with remarkably complex biochemistry. Its involvement in multiple sclerosis (MS) had been postulated soon after the discovery of the critical role NO plays in inflammation. However, the extent of NO's contribution to MS is not yet understood, party due to the often opposing roles that NO can play in cellular processes. This review briefly covers new developments in the area of NO that may be relevant to MS. It also describes recent progress in understanding the role of NO in MS, new potential targets of the action of NO in the cell, and prospects for NO-based therapies.

Original language	English
Pages (from-to)	232-238
Number of pages	7
Journal	Current Neurology and Neuroscience Reports
Volume	5
Issue number	3
DOIs	https://doi.org/10.1007/s11910-005-0051-y
State	Published - May 2005

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abstract = "Nitric oxide (NO) is a free radical signaling molecule with remarkably complex biochemistry. Its involvement in multiple sclerosis (MS) had been postulated soon after the discovery of the critical role NO plays in inflammation. However, the extent of NO's contribution to MS is not yet understood, party due to the often opposing roles that NO can play in cellular processes. This review briefly covers new developments in the area of NO that may be relevant to MS. It also describes recent progress in understanding the role of NO in MS, new potential targets of the action of NO in the cell, and prospects for NO-based therapies.",

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AU - Manganas, Louis

AU - Enikolopov, Grigori

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AB - Nitric oxide (NO) is a free radical signaling molecule with remarkably complex biochemistry. Its involvement in multiple sclerosis (MS) had been postulated soon after the discovery of the critical role NO plays in inflammation. However, the extent of NO's contribution to MS is not yet understood, party due to the often opposing roles that NO can play in cellular processes. This review briefly covers new developments in the area of NO that may be relevant to MS. It also describes recent progress in understanding the role of NO in MS, new potential targets of the action of NO in the cell, and prospects for NO-based therapies.

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DO - 10.1007/s11910-005-0051-y

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JO - Current Neurology and Neuroscience Reports

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ER -

Nitric oxide and multiple sclerosis

Abstract

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