NMDA Receptors Require Multiple Pre-opening Gating Steps for Efficient Synaptic Activity

Johansen B. Amin; Aaron Gochman; Miaomiao He; Noele Certain; Lonnie P. Wollmuth

doi:10.1016/j.neuron.2020.11.009

NMDA Receptors Require Multiple Pre-opening Gating Steps for Efficient Synaptic Activity

Johansen B. Amin
, Aaron Gochman
, Miaomiao He
, Noele Certain
, Lonnie P. Wollmuth

Neurobiology and Behavior

Stony Brook University

Stony Brook University

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

NMDA receptors are neurotransmitter-gated ion channels that regulate higher brain function. Using a unique technique to assay neurotransmitter-induced opening of the ion channel and available high-resolution structures, Amin et al. provide a framework to understand the structural underpinnings that regulate the activity of NMDA receptor activation at synapses.

Original language	English
Pages (from-to)	488-501.e4
Journal	Neuron
Volume	109
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2020.11.009
State	Published - Feb 3 2021

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10.1016/j.neuron.2020.11.009

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abstract = "NMDA receptors are neurotransmitter-gated ion channels that regulate higher brain function. Using a unique technique to assay neurotransmitter-induced opening of the ion channel and available high-resolution structures, Amin et al. provide a framework to understand the structural underpinnings that regulate the activity of NMDA receptor activation at synapses.",

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AU - Wollmuth, Lonnie P.

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AB - NMDA receptors are neurotransmitter-gated ion channels that regulate higher brain function. Using a unique technique to assay neurotransmitter-induced opening of the ion channel and available high-resolution structures, Amin et al. provide a framework to understand the structural underpinnings that regulate the activity of NMDA receptor activation at synapses.

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NMDA Receptors Require Multiple Pre-opening Gating Steps for Efficient Synaptic Activity

Abstract

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