Nociceptors: The gateway to pain

Michelino Puopolo; Lorne M. Mendell

doi:10.1016/B978-0-12-809324-5.03129-1

Nociceptors: The gateway to pain

Michelino Puopolo
, Lorne M. Mendell

Anesthesiology

Stony Brook University

Stony Brook University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Nociceptors belong to a specialized class of sensory fibers that transmit information concerning stimuli that are potentially damaging to the organism; they generally elicit a response of pain. This article discusses the properties of this important class of neuron, specifically its specialized physiology, anatomy, and biochemistry. In addition to acutely signaling the presence of a potentially damaging stimulus, nociceptors can exhibit significant plasticity in response to injury in their receptive field, and this will be discussed in the context of persistent or chronic pain.

Original language	English
Title of host publication	The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier Science Ltd.
Pages	613-624
Number of pages	12
ISBN (Electronic)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.03129-1
State	Published - Jan 1 2016

Keywords

AHP
Allodynia
Aδ axons
Gasserian ganglion
Hyperalgesia
NMDA receptor
Nociceptor development
Nociceptor plasticity
Nociceptors
Sensitization
Sodium channels
Spinal cord
TTX
Windup

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10.1016/B978-0-12-809324-5.03129-1

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title = "Nociceptors: The gateway to pain",

abstract = "Nociceptors belong to a specialized class of sensory fibers that transmit information concerning stimuli that are potentially damaging to the organism; they generally elicit a response of pain. This article discusses the properties of this important class of neuron, specifically its specialized physiology, anatomy, and biochemistry. In addition to acutely signaling the presence of a potentially damaging stimulus, nociceptors can exhibit significant plasticity in response to injury in their receptive field, and this will be discussed in the context of persistent or chronic pain.",

keywords = "AHP, Allodynia, Aδ axons, Gasserian ganglion, Hyperalgesia, NMDA receptor, Nociceptor development, Nociceptor plasticity, Nociceptors, Sensitization, Sodium channels, Spinal cord, TTX, Windup",

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AU - Mendell, Lorne M.

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AB - Nociceptors belong to a specialized class of sensory fibers that transmit information concerning stimuli that are potentially damaging to the organism; they generally elicit a response of pain. This article discusses the properties of this important class of neuron, specifically its specialized physiology, anatomy, and biochemistry. In addition to acutely signaling the presence of a potentially damaging stimulus, nociceptors can exhibit significant plasticity in response to injury in their receptive field, and this will be discussed in the context of persistent or chronic pain.

KW - AHP

KW - Allodynia

KW - Aδ axons

KW - Gasserian ganglion

KW - Hyperalgesia

KW - NMDA receptor

KW - Nociceptor development

KW - Nociceptor plasticity

KW - Nociceptors

KW - Sensitization

KW - Sodium channels

KW - Spinal cord

KW - TTX

KW - Windup

UR - https://www.scopus.com/pages/publications/85079567430

U2 - 10.1016/B978-0-12-809324-5.03129-1

DO - 10.1016/B978-0-12-809324-5.03129-1

M3 - Chapter

SP - 613

EP - 624

BT - The Curated Reference Collection in Neuroscience and Biobehavioral Psychology

PB - Elsevier Science Ltd.

ER -

Nociceptors: The gateway to pain

Abstract

Keywords

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