Optimum treatment allocation for dual-objective clinical trials with binary outcomes

Wei Zhu; Weng Kee Wong

doi:10.1080/03610920008832526

Optimum treatment allocation for dual-objective clinical trials with binary outcomes

Wei Zhu
, Weng Kee Wong

Applied Mathematics and Statistics

Stony Brook University

University of California at Los Angeles

Research output: Contribution to journal › Conference article › peer-review

9 Scopus citations

Abstract

A common problem in randomized controlled clinical trials is the optimal assignment of patients to treatment protocols. The traditional optimal design assumes a single criterion, although in reality, there are usually more than one objective in a clinical trial. In this paper, optimal treatment allocation schemes are found for a dual-objective clinical trial with a binary response. A graphical method for finding the optimal strategy is proposed and illustrative examples are discussed.

Original language	English
Pages (from-to)	957-974
Number of pages	18
Journal	Communications in Statistics - Theory and Methods
Volume	29
Issue number	5-6
DOIs	https://doi.org/10.1080/03610920008832526
State	Published - 2000
Event	The 1999 Applied Statistical Symposium of the International Chinese Statistical Association - Washington, DC, United States Duration: Jun 18 1999 → Jun 20 1999

Keywords

Compound optimal design
Constrained optimal design
Efficiency plot
Logistic regression model

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10.1080/03610920008832526

Cite this

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title = "Optimum treatment allocation for dual-objective clinical trials with binary outcomes",

abstract = "A common problem in randomized controlled clinical trials is the optimal assignment of patients to treatment protocols. The traditional optimal design assumes a single criterion, although in reality, there are usually more than one objective in a clinical trial. In this paper, optimal treatment allocation schemes are found for a dual-objective clinical trial with a binary response. A graphical method for finding the optimal strategy is proposed and illustrative examples are discussed.",

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AU - Wong, Weng Kee

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AB - A common problem in randomized controlled clinical trials is the optimal assignment of patients to treatment protocols. The traditional optimal design assumes a single criterion, although in reality, there are usually more than one objective in a clinical trial. In this paper, optimal treatment allocation schemes are found for a dual-objective clinical trial with a binary response. A graphical method for finding the optimal strategy is proposed and illustrative examples are discussed.

KW - Compound optimal design

KW - Constrained optimal design

KW - Efficiency plot

KW - Logistic regression model

UR - https://www.scopus.com/pages/publications/26844569178

U2 - 10.1080/03610920008832526

DO - 10.1080/03610920008832526

M3 - Conference article

SN - 0361-0926

VL - 29

SP - 957

EP - 974

JO - Communications in Statistics - Theory and Methods

JF - Communications in Statistics - Theory and Methods

IS - 5-6

T2 - The 1999 Applied Statistical Symposium of the International Chinese Statistical Association

Y2 - 18 June 1999 through 20 June 1999

ER -

Optimum treatment allocation for dual-objective clinical trials with binary outcomes

Abstract

Keywords

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