Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

Priyadharshini Devarajan; Susan L. Swain

doi:10.1016/j.chom.2019.02.009

Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

Priyadharshini Devarajan
, Susan L. Swain

Microbiology and Immunology

Stony Brook University

University of Massachusetts Medical School

Research output: Contribution to journal › Short survey › peer-review

12 Scopus citations

Abstract

In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a universal influenza vaccine.

Original language	English
Pages (from-to)	354-355
Number of pages	2
Journal	Cell Host and Microbe
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2019.02.009
State	Published - Mar 13 2019

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10.1016/j.chom.2019.02.009

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title = "Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?",

abstract = "In this issue of Cell Host \& Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a universal influenza vaccine.",

author = "Priyadharshini Devarajan and Swain, \{Susan L.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

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day = "13",

doi = "10.1016/j.chom.2019.02.009",

language = "English",

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T1 - Original Antigenic Sin

T2 - Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

AU - Devarajan, Priyadharshini

AU - Swain, Susan L.

PY - 2019/3/13

Y1 - 2019/3/13

N2 - In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a universal influenza vaccine.

AB - In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and with age, despite repeated exposures. Identified persistent dominant clones target conserved viral epitopes, supporting the feasibility of a universal influenza vaccine.

UR - https://www.scopus.com/pages/publications/85062070668

U2 - 10.1016/j.chom.2019.02.009

DO - 10.1016/j.chom.2019.02.009

M3 - Short survey

C2 - 30870620

SN - 1931-3128

VL - 25

SP - 354

EP - 355

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 3

ER -

Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

Abstract

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