Perspective: The promise of multi-cellular engineered living systems

Roger D. Kamm; Rashid Bashir; Natasha Arora; Roy D. Dar; Martha U. Gillette; Linda G. Griffith; Melissa L. Kemp; Kathy Kinlaw; Michael Levin; Adam C. Martin; Todd C. McDevitt; Robert M. Nerem; Mark J. Powers; Taher A. Saif; James Sharpe; Shuichi Takayama; Shoji Takeuchi; Ron Weiss; Kaiming Ye; Hannah G. Yevick; Muhammad H. Zaman

doi:10.1063/1.5038337

Perspective: The promise of multi-cellular engineered living systems

Roger D. Kamm
, Rashid Bashir
, Natasha Arora
, Roy D. Dar
, Martha U. Gillette
, Linda G. Griffith
, Melissa L. Kemp
, Kathy Kinlaw
, Michael Levin
, Adam C. Martin
, Todd C. McDevitt
, Robert M. Nerem
, Mark J. Powers
, Taher A. Saif
, James Sharpe
, Shuichi Takayama
, Shoji Takeuchi
, Ron Weiss
, Kaiming Ye
, Hannah G. Yevick

Muhammad H. Zaman

Biomedical Engineering

Binghamton University

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of "multi-cellular engineered living systems," which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered.

Original language	English
Article number	040901
Journal	APL Bioengineering
Volume	2
Issue number	4
DOIs	https://doi.org/10.1063/1.5038337
State	Published - Dec 1 2018

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Kamm, R. D., Bashir, R., Arora, N., Dar, R. D., Gillette, M. U., Griffith, L. G., Kemp, M. L., Kinlaw, K., Levin, M., Martin, A. C., McDevitt, T. C., Nerem, R. M., Powers, M. J., Saif, T. A., Sharpe, J., Takayama, S., Takeuchi, S., Weiss, R., Ye, K., ... Zaman, M. H. (2018). Perspective: The promise of multi-cellular engineered living systems. APL Bioengineering, 2(4), Article 040901. https://doi.org/10.1063/1.5038337

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title = "Perspective: The promise of multi-cellular engineered living systems",

abstract = "Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of {"}multi-cellular engineered living systems,{"} which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered.",

author = "Kamm, \{Roger D.\} and Rashid Bashir and Natasha Arora and Dar, \{Roy D.\} and Gillette, \{Martha U.\} and Griffith, \{Linda G.\} and Kemp, \{Melissa L.\} and Kathy Kinlaw and Michael Levin and Martin, \{Adam C.\} and McDevitt, \{Todd C.\} and Nerem, \{Robert M.\} and Powers, \{Mark J.\} and Saif, \{Taher A.\} and James Sharpe and Shuichi Takayama and Shoji Takeuchi and Ron Weiss and Kaiming Ye and Yevick, \{Hannah G.\} and Zaman, \{Muhammad H.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Author(s).",

year = "2018",

month = dec,

day = "1",

doi = "10.1063/1.5038337",

language = "English",

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Kamm, RD, Bashir, R, Arora, N, Dar, RD, Gillette, MU, Griffith, LG, Kemp, ML, Kinlaw, K, Levin, M, Martin, AC, McDevitt, TC, Nerem, RM, Powers, MJ, Saif, TA, Sharpe, J, Takayama, S, Takeuchi, S, Weiss, R, Ye, K, Yevick, HG & Zaman, MH 2018, 'Perspective: The promise of multi-cellular engineered living systems', APL Bioengineering, vol. 2, no. 4, 040901. https://doi.org/10.1063/1.5038337

TY - JOUR

T1 - Perspective

T2 - The promise of multi-cellular engineered living systems

AU - Kamm, Roger D.

AU - Bashir, Rashid

AU - Arora, Natasha

AU - Dar, Roy D.

AU - Gillette, Martha U.

AU - Griffith, Linda G.

AU - Kemp, Melissa L.

AU - Kinlaw, Kathy

AU - Levin, Michael

AU - Martin, Adam C.

AU - McDevitt, Todd C.

AU - Nerem, Robert M.

AU - Powers, Mark J.

AU - Saif, Taher A.

AU - Sharpe, James

AU - Takayama, Shuichi

AU - Takeuchi, Shoji

AU - Weiss, Ron

AU - Ye, Kaiming

AU - Yevick, Hannah G.

AU - Zaman, Muhammad H.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of "multi-cellular engineered living systems," which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered.

AB - Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of "multi-cellular engineered living systems," which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered.

UR - https://www.scopus.com/pages/publications/85082844233

U2 - 10.1063/1.5038337

DO - 10.1063/1.5038337

M3 - Article

SN - 2473-2877

VL - 2

JO - APL Bioengineering

JF - APL Bioengineering

IS - 4

M1 - 040901

ER -

Perspective: The promise of multi-cellular engineered living systems

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