Phages will out: Strategies of host cell lysis

Ry Young; Ing Nang Wang; William D. Roof

doi:10.1016/S0966-842X(00)01705-4

Phages will out: Strategies of host cell lysis

Ry Young
, Ing Nang Wang
, William D. Roof

Biology

University at Albany

Texas A&M University

Research output: Contribution to journal › Review article › peer-review

376 Scopus citations

Abstract

Most phages accomplish host lysis using a muralytic enzyme, or endolysin, and a holin, which permeabilizes the membrane at a programmed time and thus controls the length of the vegetative cycle. By contrast, lytic single-stranded RNA and DNA phages accomplish lysis by producing a single lysis protein without muralytic activity.

Original language	English
Pages (from-to)	120-128
Number of pages	9
Journal	Trends in Microbiology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/S0966-842X(00)01705-4
State	Published - Mar 1 2000

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title = "Phages will out: Strategies of host cell lysis",

abstract = "Most phages accomplish host lysis using a muralytic enzyme, or endolysin, and a holin, which permeabilizes the membrane at a programmed time and thus controls the length of the vegetative cycle. By contrast, lytic single-stranded RNA and DNA phages accomplish lysis by producing a single lysis protein without muralytic activity.",

author = "Ry Young and Wang, \{Ing Nang\} and Roof, \{William D.\}",

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T1 - Phages will out

T2 - Strategies of host cell lysis

AU - Young, Ry

AU - Wang, Ing Nang

AU - Roof, William D.

PY - 2000/3/1

Y1 - 2000/3/1

N2 - Most phages accomplish host lysis using a muralytic enzyme, or endolysin, and a holin, which permeabilizes the membrane at a programmed time and thus controls the length of the vegetative cycle. By contrast, lytic single-stranded RNA and DNA phages accomplish lysis by producing a single lysis protein without muralytic activity.

AB - Most phages accomplish host lysis using a muralytic enzyme, or endolysin, and a holin, which permeabilizes the membrane at a programmed time and thus controls the length of the vegetative cycle. By contrast, lytic single-stranded RNA and DNA phages accomplish lysis by producing a single lysis protein without muralytic activity.

UR - https://www.scopus.com/pages/publications/0034162940

U2 - 10.1016/S0966-842X(00)01705-4

DO - 10.1016/S0966-842X(00)01705-4

M3 - Review article

C2 - 10707065

SN - 0966-842X

VL - 8

SP - 120

EP - 128

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 3

ER -

Phages will out: Strategies of host cell lysis

Abstract

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