Phospholipase D structure and regulation

Michael A. Frohman; Andrew J. Morris

doi:10.1016/S0009-3084(99)00025-0

Phospholipase D structure and regulation

Michael A. Frohman
, Andrew J. Morris

Pharmacological Sciences

Stony Brook University

Stony Brook University

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

The recent identification of cDNA clones for phospholipase D has opened the door to new types of investigations into its structure and regulation. PLD activity has been found to be encoded by at least two different genes that contain catalytic domains that relate their mechanism of action to phosphodiesterases. In vivo roles for PLD suggest that it may be important for multiples steps in regulated secretion and membrane biogenesis. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	127-140
Number of pages	14
Journal	Chemistry and Physics of Lipids
Volume	98
Issue number	1-2
DOIs	https://doi.org/10.1016/S0009-3084(99)00025-0
State	Published - Apr 1999

Keywords

ARF
PLD1
PLD2
Phospholipase D
Protein kinase C
Rho

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10.1016/S0009-3084(99)00025-0

Cite this

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title = "Phospholipase D structure and regulation",

abstract = "The recent identification of cDNA clones for phospholipase D has opened the door to new types of investigations into its structure and regulation. PLD activity has been found to be encoded by at least two different genes that contain catalytic domains that relate their mechanism of action to phosphodiesterases. In vivo roles for PLD suggest that it may be important for multiples steps in regulated secretion and membrane biogenesis. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "ARF, PLD1, PLD2, Phospholipase D, Protein kinase C, Rho",

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AB - The recent identification of cDNA clones for phospholipase D has opened the door to new types of investigations into its structure and regulation. PLD activity has been found to be encoded by at least two different genes that contain catalytic domains that relate their mechanism of action to phosphodiesterases. In vivo roles for PLD suggest that it may be important for multiples steps in regulated secretion and membrane biogenesis. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - ARF

KW - PLD1

KW - PLD2

KW - Phospholipase D

KW - Protein kinase C

KW - Rho

UR - https://www.scopus.com/pages/publications/0033020809

U2 - 10.1016/S0009-3084(99)00025-0

DO - 10.1016/S0009-3084(99)00025-0

M3 - Article

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VL - 98

SP - 127

EP - 140

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

IS - 1-2

ER -

Phospholipase D structure and regulation

Abstract

Keywords

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