Phosphorothioate and phosphoramide analogs of dihydroxyacetone phosphate

Rachel Duncan; Dale G. Drueckhammer

doi:10.1016/S0040-4039(00)60764-5

Phosphorothioate and phosphoramide analogs of dihydroxyacetone phosphate

Rachel Duncan
, Dale G. Drueckhammer

Chemistry

Stony Brook University

Stanford University

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The phosphorothioate analog of dihydroxyacetone phosphate has been prepared by reaction of bromohydroxyacetone with trisodium thiophosphate in aqueous solution. The enzymatic oxidation of 3-amino-1,2-propanediol phosphoramide with glycerol-3-phosphate oxidase has been demonstrated as a route to the corresponding phosphoramide analog.

Original language	English
Pages (from-to)	1733-1736
Number of pages	4
Journal	Tetrahedron Letters
Volume	34
Issue number	11
DOIs	https://doi.org/10.1016/S0040-4039(00)60764-5
State	Published - Mar 12 1993

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title = "Phosphorothioate and phosphoramide analogs of dihydroxyacetone phosphate",

abstract = "The phosphorothioate analog of dihydroxyacetone phosphate has been prepared by reaction of bromohydroxyacetone with trisodium thiophosphate in aqueous solution. The enzymatic oxidation of 3-amino-1,2-propanediol phosphoramide with glycerol-3-phosphate oxidase has been demonstrated as a route to the corresponding phosphoramide analog.",

author = "Rachel Duncan and Drueckhammer, \{Dale G.\}",

year = "1993",

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doi = "10.1016/S0040-4039(00)60764-5",

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T1 - Phosphorothioate and phosphoramide analogs of dihydroxyacetone phosphate

AU - Duncan, Rachel

AU - Drueckhammer, Dale G.

PY - 1993/3/12

Y1 - 1993/3/12

N2 - The phosphorothioate analog of dihydroxyacetone phosphate has been prepared by reaction of bromohydroxyacetone with trisodium thiophosphate in aqueous solution. The enzymatic oxidation of 3-amino-1,2-propanediol phosphoramide with glycerol-3-phosphate oxidase has been demonstrated as a route to the corresponding phosphoramide analog.

AB - The phosphorothioate analog of dihydroxyacetone phosphate has been prepared by reaction of bromohydroxyacetone with trisodium thiophosphate in aqueous solution. The enzymatic oxidation of 3-amino-1,2-propanediol phosphoramide with glycerol-3-phosphate oxidase has been demonstrated as a route to the corresponding phosphoramide analog.

UR - https://www.scopus.com/pages/publications/0027465014

U2 - 10.1016/S0040-4039(00)60764-5

DO - 10.1016/S0040-4039(00)60764-5

M3 - Article

SN - 0040-4039

VL - 34

SP - 1733

EP - 1736

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 11

ER -

Phosphorothioate and phosphoramide analogs of dihydroxyacetone phosphate

Abstract

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