Abstract
The mesoderm development (mesd) functional interval is essential for primitive streak formation and mesoderm induction. Mesd is defined by overlapping albino (c) deletions on chromosome 7. We have constructed a bacterial artificial chromosome (BAC) contig that spans the mesd functional region. BAC end-sequence identifies three segments that recognize novel expressed sequences. Localization of the proximal breakpoints from Del(7)Tyr(c-3YPSd) and Del(7)Tyr(c-112K) within the contig defines a deletion interval of 310-350 kb that is essential for mesd function. Importantly, using BAC transgene rescue, we define a 75-kb mesd critical region containing at least one expressed sequence. (C) 2000 Academic Press.
| Original language | English |
|---|---|
| Pages (from-to) | 322-329 |
| Number of pages | 8 |
| Journal | Genomics |
| Volume | 68 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 15 2000 |
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