Platelet damage accumulation: In vitro and mathematical models

J. Sheriff; M. Nobili; J. U. Morbiducci; A. Redaelli; J. Jesty; D. Bluestein

doi:10.1109/NEBC.2007.4413347

Platelet damage accumulation: In vitro and mathematical models

J. Sheriff
, M. Nobili
, J. U. Morbiducci
, A. Redaelli
, J. Jesty
, D. Bluestein

Biomedical Engineering

Stony Brook University

Stony Brook University
Polytechnic University of Milan
Marche Polytechnic University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

A phenomenological model for platelet cumulative damage was developed to express the platelet activation state (PAS) in response to a specific shear stress loading waveform. Genetic algorithms (GAs) were used for model identification. The model was fine-tuned using parameters obtained in vitro by application of a shear stress loading waveform to a Hemodynamic Shearing Device (HSD). The PAS was measured temporally using a modified prothrombinase method. The proposed analytical model and PAS prediction agree well with and follow the same trend as the experimental results.

Original language	English
Title of host publication	33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	199-200
Number of pages	2
ISBN (Print)	1424410339, 9781424410330
DOIs	https://doi.org/10.1109/NEBC.2007.4413347
State	Published - 2007
Event	33rd Annual Northeast Bioengineering Conference, NEBC - Stony Brook, NY, United States Duration: Mar 10 2007 → Mar 11 2007

Publication series

Name	Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC

Conference

Conference	33rd Annual Northeast Bioengineering Conference, NEBC
Country/Territory	United States
City	Stony Brook, NY
Period	03/10/07 → 03/11/07

Access to Document

10.1109/NEBC.2007.4413347

Cite this

Sheriff, J., Nobili, M., Morbiducci, J. U., Redaelli, A., Jesty, J., & Bluestein, D. (2007). Platelet damage accumulation: In vitro and mathematical models. In 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC (pp. 199-200). Article 4413347 (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEBC.2007.4413347

Sheriff, J. ; Nobili, M. ; Morbiducci, J. U. et al. / Platelet damage accumulation : In vitro and mathematical models. 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC. Institute of Electrical and Electronics Engineers Inc., 2007. pp. 199-200 (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC).

@inproceedings{a3b07b0c1a504cdbac8c568bf8ec0f67,

title = "Platelet damage accumulation: In vitro and mathematical models",

abstract = "A phenomenological model for platelet cumulative damage was developed to express the platelet activation state (PAS) in response to a specific shear stress loading waveform. Genetic algorithms (GAs) were used for model identification. The model was fine-tuned using parameters obtained in vitro by application of a shear stress loading waveform to a Hemodynamic Shearing Device (HSD). The PAS was measured temporally using a modified prothrombinase method. The proposed analytical model and PAS prediction agree well with and follow the same trend as the experimental results.",

author = "J. Sheriff and M. Nobili and Morbiducci, \{J. U.\} and A. Redaelli and J. Jesty and D. Bluestein",

year = "2007",

doi = "10.1109/NEBC.2007.4413347",

language = "English",

isbn = "1424410339",

series = "Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "199--200",

booktitle = "33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC",

note = "33rd Annual Northeast Bioengineering Conference, NEBC ; Conference date: 10-03-2007 Through 11-03-2007",

}

Sheriff, J, Nobili, M, Morbiducci, JU, Redaelli, A, Jesty, J & Bluestein, D 2007, Platelet damage accumulation: In vitro and mathematical models. in 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC., 4413347, Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, Institute of Electrical and Electronics Engineers Inc., pp. 199-200, 33rd Annual Northeast Bioengineering Conference, NEBC, Stony Brook, NY, United States, 03/10/07. https://doi.org/10.1109/NEBC.2007.4413347

Platelet damage accumulation: In vitro and mathematical models. / Sheriff, J.; Nobili, M.; Morbiducci, J. U. et al.
33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC. Institute of Electrical and Electronics Engineers Inc., 2007. p. 199-200 4413347 (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Jesty, J.

AU - Bluestein, D.

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AB - A phenomenological model for platelet cumulative damage was developed to express the platelet activation state (PAS) in response to a specific shear stress loading waveform. Genetic algorithms (GAs) were used for model identification. The model was fine-tuned using parameters obtained in vitro by application of a shear stress loading waveform to a Hemodynamic Shearing Device (HSD). The PAS was measured temporally using a modified prothrombinase method. The proposed analytical model and PAS prediction agree well with and follow the same trend as the experimental results.

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M3 - Conference contribution

SN - 1424410339

SN - 9781424410330

T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC

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PB - Institute of Electrical and Electronics Engineers Inc.

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ER -

Sheriff J, Nobili M, Morbiducci JU, Redaelli A, Jesty J, Bluestein D. Platelet damage accumulation: In vitro and mathematical models. In 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC. Institute of Electrical and Electronics Engineers Inc. 2007. p. 199-200. 4413347. (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC). doi: 10.1109/NEBC.2007.4413347

Platelet damage accumulation: In vitro and mathematical models

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