TY - GEN
T1 - Poly(lactide)-poly(ethylene oxide)-poly(lactide) triblock copolymers
T2 - Synthesis and thermal properties
AU - Sanabria-DeLong, Naomi
AU - Aamer, Khaled A.
AU - Agrawal, Sarvesh K.
AU - Bhatia, Surita R.
AU - Tew, Gregory N.
PY - 2006
Y1 - 2006
N2 - Poly (lactide) - poly (ethylene oxide) - poly (lactide) [PLA-PEO-PLA] triblock copolymers are of particular interest in the biomedical field due to their biocompatibility and their ability to form hydrogels in water. These hydrogels have potential applications in both drug delivery applications and tissue engineering. They are particularly interesting because their mechanical properties can be influenced by both the length of the PLA hydrophobic end-blocks and by the ability of the PLA end-blocks to crystallize. Copolymers with crystallizable PLLA end-groups form stiffer gels, while copolymers with amorphous stereorandom PLA form weaker hydrogels. We investigate here the thermal properties of these triblock copolymers in their neat state to establish the presence of crystalline PLLA before incorporation into hydrogels and the effect of aging.
AB - Poly (lactide) - poly (ethylene oxide) - poly (lactide) [PLA-PEO-PLA] triblock copolymers are of particular interest in the biomedical field due to their biocompatibility and their ability to form hydrogels in water. These hydrogels have potential applications in both drug delivery applications and tissue engineering. They are particularly interesting because their mechanical properties can be influenced by both the length of the PLA hydrophobic end-blocks and by the ability of the PLA end-blocks to crystallize. Copolymers with crystallizable PLLA end-groups form stiffer gels, while copolymers with amorphous stereorandom PLA form weaker hydrogels. We investigate here the thermal properties of these triblock copolymers in their neat state to establish the presence of crystalline PLLA before incorporation into hydrogels and the effect of aging.
UR - https://www.scopus.com/pages/publications/36849085309
U2 - 10.1021/bk-2006-0939.ch010
DO - 10.1021/bk-2006-0939.ch010
M3 - Conference contribution
SN - 084123972X
SN - 9780841239722
T3 - ACS Symposium Series
SP - 156
EP - 167
BT - Degradable Polymers and Materials Principles and Practice
PB - American Chemical Society
ER -