Potential of Machine-Vision Light Microscopy in Toxicologic Pathology

D. Lansing Taylor; Robbin Debiasio; Greg Larocca; David Pane; Penny Post; John Kolega; Ken Giuliano; Kevin Burton; Bert Gough; Alasdair Dow; Judy yu; Alan S. Waggoner; Daniel L. Farkas

doi:10.1177/019262339402200208

Potential of Machine-Vision Light Microscopy in Toxicologic Pathology

D. Lansing Taylor
, Robbin Debiasio
, Greg Larocca
, David Pane
, Penny Post
, John Kolega
, Ken Giuliano
, Kevin Burton
, Bert Gough
, Alasdair Dow
, Judy yu
, Alan S. Waggoner
, Daniel L. Farkas

Department of Pathology and Anatomical Sciences

University at Buffalo

Carnegie Mellon University

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Major developments in machine-vision light microscopy and in reagent chemistry have led to a renaissance and revolution in the use of the light microscope in biology, biotechnology, and medicine. The potential use of this technology in the field of toxicologic pathology is discussed. It is suggested that a combination of investigating living cells and tissues and fixed samples using the new technologies will lead to understanding mechanisms of toxicity. Examples of the use of the methods in basic cell biology and medicine are presented.

Original language	English
Pages (from-to)	145-159
Number of pages	15
Journal	Toxicologic Pathology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1177/019262339402200208
State	Published - Mar 1994

Keywords

3-dimensional microscopy
Fluorescence
fluorescent analogs
immunofluorescence
in situ hybridization
video-enhanced contrast

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title = "Potential of Machine-Vision Light Microscopy in Toxicologic Pathology",

abstract = "Major developments in machine-vision light microscopy and in reagent chemistry have led to a renaissance and revolution in the use of the light microscope in biology, biotechnology, and medicine. The potential use of this technology in the field of toxicologic pathology is discussed. It is suggested that a combination of investigating living cells and tissues and fixed samples using the new technologies will lead to understanding mechanisms of toxicity. Examples of the use of the methods in basic cell biology and medicine are presented.",

keywords = "3-dimensional microscopy, Fluorescence, fluorescent analogs, immunofluorescence, in situ hybridization, video-enhanced contrast",

author = "Taylor, \{D. Lansing\} and Robbin Debiasio and Greg Larocca and David Pane and Penny Post and John Kolega and Ken Giuliano and Kevin Burton and Bert Gough and Alasdair Dow and Judy yu and Waggoner, \{Alan S.\} and Farkas, \{Daniel L.\}",

year = "1994",

month = mar,

doi = "10.1177/019262339402200208",

language = "English",

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pages = "145--159",

journal = "Toxicologic Pathology",

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T1 - Potential of Machine-Vision Light Microscopy in Toxicologic Pathology

AU - Taylor, D. Lansing

AU - Debiasio, Robbin

AU - Larocca, Greg

AU - Pane, David

AU - Post, Penny

AU - Kolega, John

AU - Giuliano, Ken

AU - Burton, Kevin

AU - Gough, Bert

AU - Dow, Alasdair

AU - yu, Judy

AU - Waggoner, Alan S.

AU - Farkas, Daniel L.

PY - 1994/3

Y1 - 1994/3

N2 - Major developments in machine-vision light microscopy and in reagent chemistry have led to a renaissance and revolution in the use of the light microscope in biology, biotechnology, and medicine. The potential use of this technology in the field of toxicologic pathology is discussed. It is suggested that a combination of investigating living cells and tissues and fixed samples using the new technologies will lead to understanding mechanisms of toxicity. Examples of the use of the methods in basic cell biology and medicine are presented.

AB - Major developments in machine-vision light microscopy and in reagent chemistry have led to a renaissance and revolution in the use of the light microscope in biology, biotechnology, and medicine. The potential use of this technology in the field of toxicologic pathology is discussed. It is suggested that a combination of investigating living cells and tissues and fixed samples using the new technologies will lead to understanding mechanisms of toxicity. Examples of the use of the methods in basic cell biology and medicine are presented.

KW - 3-dimensional microscopy

KW - Fluorescence

KW - fluorescent analogs

KW - immunofluorescence

KW - in situ hybridization

KW - video-enhanced contrast

UR - https://www.scopus.com/pages/publications/0028022558

U2 - 10.1177/019262339402200208

DO - 10.1177/019262339402200208

M3 - Article

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SN - 0192-6233

VL - 22

SP - 145

EP - 159

JO - Toxicologic Pathology

JF - Toxicologic Pathology

IS - 2

ER -

Potential of Machine-Vision Light Microscopy in Toxicologic Pathology

Abstract

Keywords

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