PREDNISONE SIDE-EFFECTS AND SERUM-PROTEIN LEVELS. A Collaborative Study

George P. Lewis; William J. Jusko; Christopher W. Burke; Linda Graves; Collaborative Drug Surveillance Program Boston Collaborative Drug Surveillance Program

doi:10.1016/S0140-6736(71)92738-3

PREDNISONE SIDE-EFFECTS AND SERUM-PROTEIN LEVELS. A Collaborative Study

George P. Lewis
, William J. Jusko
, Christopher W. Burke
, Linda Graves
, Collaborative Drug Surveillance Program Boston Collaborative Drug Surveillance Program

Pharmaceutical Sciences

University at Buffalo

VA Medical Center
Imperial College London
Boston University

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Abstract

Comprehensive drug surveillance of 240 medical inpatients receiving prednisone has revealed a correlation between the frequency of side-effects, the mean daily prednisone dose, and the serum-albumin. When serum-albumin concentration is less than 2·5 g. per 100 ml., the frequency of prednisone side-effects is doubled. The binding of prednisolone, the active metabolite of prednisone, to albumin and corticosteroid-binding globulin was measured. The binding data were utilised, together with other published information, to develop a pharmacodynamic model to determine the role of protein binding on prednisolone distribution. It is shown that hypoalbuminæmia can result in increased free prednisolone levels in the body, which partly explains the increased frequency of side-effects in such patients.

Original language	English
Pages (from-to)	778-781
Number of pages	4
Journal	The Lancet
Volume	298
Issue number	7728
DOIs	https://doi.org/10.1016/S0140-6736(71)92738-3
State	Published - Oct 9 1971

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title = "PREDNISONE SIDE-EFFECTS AND SERUM-PROTEIN LEVELS. A Collaborative Study",

abstract = "Comprehensive drug surveillance of 240 medical inpatients receiving prednisone has revealed a correlation between the frequency of side-effects, the mean daily prednisone dose, and the serum-albumin. When serum-albumin concentration is less than 2·5 g. per 100 ml., the frequency of prednisone side-effects is doubled. The binding of prednisolone, the active metabolite of prednisone, to albumin and corticosteroid-binding globulin was measured. The binding data were utilised, together with other published information, to develop a pharmacodynamic model to determine the role of protein binding on prednisolone distribution. It is shown that hypoalbumin{\ae}mia can result in increased free prednisolone levels in the body, which partly explains the increased frequency of side-effects in such patients.",

author = "Lewis, \{George P.\} and Jusko, \{William J.\} and Burke, \{Christopher W.\} and Linda Graves and \{Boston Collaborative Drug Surveillance Program\}, \{Collaborative Drug Surveillance Program\}",

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doi = "10.1016/S0140-6736(71)92738-3",

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AU - Lewis, George P.

AU - Jusko, William J.

AU - Burke, Christopher W.

AU - Graves, Linda

AU - Boston Collaborative Drug Surveillance Program, Collaborative Drug Surveillance Program

PY - 1971/10/9

Y1 - 1971/10/9

N2 - Comprehensive drug surveillance of 240 medical inpatients receiving prednisone has revealed a correlation between the frequency of side-effects, the mean daily prednisone dose, and the serum-albumin. When serum-albumin concentration is less than 2·5 g. per 100 ml., the frequency of prednisone side-effects is doubled. The binding of prednisolone, the active metabolite of prednisone, to albumin and corticosteroid-binding globulin was measured. The binding data were utilised, together with other published information, to develop a pharmacodynamic model to determine the role of protein binding on prednisolone distribution. It is shown that hypoalbuminæmia can result in increased free prednisolone levels in the body, which partly explains the increased frequency of side-effects in such patients.

AB - Comprehensive drug surveillance of 240 medical inpatients receiving prednisone has revealed a correlation between the frequency of side-effects, the mean daily prednisone dose, and the serum-albumin. When serum-albumin concentration is less than 2·5 g. per 100 ml., the frequency of prednisone side-effects is doubled. The binding of prednisolone, the active metabolite of prednisone, to albumin and corticosteroid-binding globulin was measured. The binding data were utilised, together with other published information, to develop a pharmacodynamic model to determine the role of protein binding on prednisolone distribution. It is shown that hypoalbuminæmia can result in increased free prednisolone levels in the body, which partly explains the increased frequency of side-effects in such patients.

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DO - 10.1016/S0140-6736(71)92738-3

M3 - Article

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JO - The Lancet

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IS - 7728

ER -

PREDNISONE SIDE-EFFECTS AND SERUM-PROTEIN LEVELS. A Collaborative Study

Abstract

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