Presence of Pili on the Surface of Francisella tularensis

Horacio Gil; Jorge L. Benach; David G. Thanassi

doi:10.1128/IAI.72.5.3042-3047.2004

Presence of Pili on the Surface of Francisella tularensis

Stony Brook University

Stony Brook University

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63 Scopus citations

Abstract

Francisella tularensis is a highly infectious gram-negative bacterium with potential for use as a bioweapon. Analysis of the F. tularensis live vaccine strain (LVS) ultrastructure by electron microscopy revealed the presence of long, thin fibers, similar in appearance to type 4 pili. The highly virulent F. tularensis Schu S4 strain was found to contain type 4 pilus genes, and we confirmed that these genes are present and expressed in the LVS.

Original language	English
Pages (from-to)	3042-3047
Number of pages	6
Journal	Infection and Immunity
Volume	72
Issue number	5
DOIs	https://doi.org/10.1128/IAI.72.5.3042-3047.2004
State	Published - May 2004

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10.1128/IAI.72.5.3042-3047.2004

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title = "Presence of Pili on the Surface of Francisella tularensis",

abstract = "Francisella tularensis is a highly infectious gram-negative bacterium with potential for use as a bioweapon. Analysis of the F. tularensis live vaccine strain (LVS) ultrastructure by electron microscopy revealed the presence of long, thin fibers, similar in appearance to type 4 pili. The highly virulent F. tularensis Schu S4 strain was found to contain type 4 pilus genes, and we confirmed that these genes are present and expressed in the LVS.",

author = "Horacio Gil and Benach, \{Jorge L.\} and Thanassi, \{David G.\}",

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AU - Gil, Horacio

AU - Benach, Jorge L.

AU - Thanassi, David G.

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N2 - Francisella tularensis is a highly infectious gram-negative bacterium with potential for use as a bioweapon. Analysis of the F. tularensis live vaccine strain (LVS) ultrastructure by electron microscopy revealed the presence of long, thin fibers, similar in appearance to type 4 pili. The highly virulent F. tularensis Schu S4 strain was found to contain type 4 pilus genes, and we confirmed that these genes are present and expressed in the LVS.

AB - Francisella tularensis is a highly infectious gram-negative bacterium with potential for use as a bioweapon. Analysis of the F. tularensis live vaccine strain (LVS) ultrastructure by electron microscopy revealed the presence of long, thin fibers, similar in appearance to type 4 pili. The highly virulent F. tularensis Schu S4 strain was found to contain type 4 pilus genes, and we confirmed that these genes are present and expressed in the LVS.

UR - https://www.scopus.com/pages/publications/2142755863

U2 - 10.1128/IAI.72.5.3042-3047.2004

DO - 10.1128/IAI.72.5.3042-3047.2004

M3 - Article

C2 - 15102818

SN - 0019-9567

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SP - 3042

EP - 3047

JO - Infection and Immunity

JF - Infection and Immunity

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ER -

Presence of Pili on the Surface of Francisella tularensis

Abstract

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