Prodrugs of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis and evaluation of the antitumor activity

Yong Kim; Young Jae You; Nguyen Hai Nam; Byung Zun Ahn

doi:10.1016/S0960-894X(02)00758-8

Prodrugs of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis and evaluation of the antitumor activity

Yong Kim
, Young Jae You
, Nguyen Hai Nam
, Byung Zun Ahn

Pharmaceutical Sciences

University at Buffalo

Chungnam National University

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A series of prodrugs of 4′-demethyl-4-deoxypodophyllotoxin (DDPT) including carbamates (3-8), a carbonate (9) and water-soluble amino acid derivatives (10-17) were prepared and tested for their antitumor activity. The carbamate 6 (2-hydroxyethylcarbamoyl-DDPT), carbonate 9 (2-chloroethyloxycarbonyl-DDPT), and most of amino acid prodrugs (12-17) showed enhanced antitumor activity.

Original language	English
Pages (from-to)	3435-3438
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(02)00758-8
State	Published - Dec 2002

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title = "Prodrugs of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis and evaluation of the antitumor activity",

abstract = "A series of prodrugs of 4′-demethyl-4-deoxypodophyllotoxin (DDPT) including carbamates (3-8), a carbonate (9) and water-soluble amino acid derivatives (10-17) were prepared and tested for their antitumor activity. The carbamate 6 (2-hydroxyethylcarbamoyl-DDPT), carbonate 9 (2-chloroethyloxycarbonyl-DDPT), and most of amino acid prodrugs (12-17) showed enhanced antitumor activity.",

author = "Yong Kim and You, \{Young Jae\} and Nam, \{Nguyen Hai\} and Ahn, \{Byung Zun\}",

year = "2002",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Prodrugs of 4′-demethyl-4-deoxypodophyllotoxin

T2 - Synthesis and evaluation of the antitumor activity

AU - Kim, Yong

AU - You, Young Jae

AU - Nam, Nguyen Hai

AU - Ahn, Byung Zun

PY - 2002/12

Y1 - 2002/12

N2 - A series of prodrugs of 4′-demethyl-4-deoxypodophyllotoxin (DDPT) including carbamates (3-8), a carbonate (9) and water-soluble amino acid derivatives (10-17) were prepared and tested for their antitumor activity. The carbamate 6 (2-hydroxyethylcarbamoyl-DDPT), carbonate 9 (2-chloroethyloxycarbonyl-DDPT), and most of amino acid prodrugs (12-17) showed enhanced antitumor activity.

AB - A series of prodrugs of 4′-demethyl-4-deoxypodophyllotoxin (DDPT) including carbamates (3-8), a carbonate (9) and water-soluble amino acid derivatives (10-17) were prepared and tested for their antitumor activity. The carbamate 6 (2-hydroxyethylcarbamoyl-DDPT), carbonate 9 (2-chloroethyloxycarbonyl-DDPT), and most of amino acid prodrugs (12-17) showed enhanced antitumor activity.

UR - https://www.scopus.com/pages/publications/0036888356

U2 - 10.1016/S0960-894X(02)00758-8

DO - 10.1016/S0960-894X(02)00758-8

M3 - Article

C2 - 12419378

SN - 0960-894X

VL - 12

SP - 3435

EP - 3438

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Prodrugs of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis and evaluation of the antitumor activity

Abstract

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