Prostacyclin synthesis by the corpora cavernosa of the human penis: Evidence for muscarinic control and pathological implications

J. Y. Jeremy; R. J. Morgan; D. P. Mikhailidis; P. Dandona

doi:10.1016/0262-1746(86)90188-5

Prostacyclin synthesis by the corpora cavernosa of the human penis: Evidence for muscarinic control and pathological implications

J. Y. Jeremy
, R. J. Morgan
, D. P. Mikhailidis
, P. Dandona

Medicine

University at Buffalo

Departments of Chemical Pathology and Human Metabolism
Royal Free London NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

The present study demonstrates that human corpus cavernosum tissue has the capacity to produce prostacyclin (PGI₂), a vasodilator and potent inhibitor of platelet aggregation. The release of PGI2 was stimulated by cholinergic (muscarinic) but not adrenergic agents. Since penile erection in man is dependent upon parasympathetic stimulation, the vasodilatory action of PGI₂ may contribute to the initiation and maintenance of erection.

Original language	English
Pages (from-to)	211-216
Number of pages	6
Journal	Prostaglandins Leukotrienes and Medicine
Volume	23
Issue number	2-3
DOIs	https://doi.org/10.1016/0262-1746(86)90188-5
State	Published - Aug 1986

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abstract = "The present study demonstrates that human corpus cavernosum tissue has the capacity to produce prostacyclin (PGI2), a vasodilator and potent inhibitor of platelet aggregation. The release of PGI2 was stimulated by cholinergic (muscarinic) but not adrenergic agents. Since penile erection in man is dependent upon parasympathetic stimulation, the vasodilatory action of PGI2 may contribute to the initiation and maintenance of erection.",

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AB - The present study demonstrates that human corpus cavernosum tissue has the capacity to produce prostacyclin (PGI2), a vasodilator and potent inhibitor of platelet aggregation. The release of PGI2 was stimulated by cholinergic (muscarinic) but not adrenergic agents. Since penile erection in man is dependent upon parasympathetic stimulation, the vasodilatory action of PGI2 may contribute to the initiation and maintenance of erection.

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Prostacyclin synthesis by the corpora cavernosa of the human penis: Evidence for muscarinic control and pathological implications

Abstract

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