TY - JOUR
T1 - Psychiatric genetics in the diverse landscape of Latin American populations
AU - Latin American Genomics Consortium
AU - Bruxel, Estela M.
AU - Rovaris, Diego L.
AU - Belangero, Sintia I.
AU - Chavarría-Soley, Gabriela
AU - Cuellar-Barboza, Alfredo B.
AU - Martínez-Magaña, José J.
AU - Nagamatsu, Sheila T.
AU - Nievergelt, Caroline M.
AU - Núñez-Ríos, Diana L.
AU - Ota, Vanessa K.
AU - Peterson, Roseann E.
AU - Sloofman, Laura G.
AU - Adams, Amy M.
AU - Albino, Elinette
AU - Alvarado, Angel T.
AU - Andrade-Brito, Diego
AU - Arguello-Pascualli, Paola Y.
AU - Bandeira, Cibele E.
AU - Bau, Claiton H.D.
AU - Bulik, Cynthia M.
AU - Buxbaum, Joseph D.
AU - Cappi, Carolina
AU - Corral-Frias, Nadia S.
AU - Corrales, Alejo
AU - Corsi-Zuelli, Fabiana
AU - Crowley, James J.
AU - Cupertino, Renata B.
AU - da Silva, Bruna S.
AU - De Almeida, Suzannah S.
AU - De la Hoz, Juan F.
AU - Forero, Diego A.
AU - Fries, Gabriel R.
AU - Gelernter, Joel
AU - González-Giraldo, Yeimy
AU - Grevet, Eugenio H.
AU - Grice, Dorothy E.
AU - Hernández-Garayua, Adriana
AU - Hettema, John M.
AU - Ibáñez, Agustín
AU - Ionita-Laza, Iuliana
AU - Lattig, Maria Claudia
AU - Lima, Yago C.
AU - Lin, Yi Sian
AU - López-León, Sandra
AU - Loureiro, Camila M.
AU - Martínez-Cerdeño, Verónica
AU - Martínez-Levy, Gabriela A.
AU - Melin, Kyle
AU - Moreno-De-Luca, Daniel
AU - Muniz Carvalho, Carolina
N1 - Publisher Copyright: © Springer Nature America, Inc. 2025.
PY - 2025/5
Y1 - 2025/5
N2 - Psychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations. Latin America and the Caribbean, regions marked by diverse genetic admixture, distinct environments and healthcare disparities, remain critically understudied in psychiatric genomics. This threatens access to precision psychiatry, where diversity is crucial for innovation and equity. This Review evaluates the current state and advancements in psychiatric genomics within Latin America and the Caribbean, discusses the prevalence and burden of psychiatric disorders, explores contributions to psychiatric GWASs from these regions and highlights methods that account for genetic diversity. We also identify existing gaps and challenges and propose recommendations to promote equity in psychiatric genomics.
AB - Psychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations. Latin America and the Caribbean, regions marked by diverse genetic admixture, distinct environments and healthcare disparities, remain critically understudied in psychiatric genomics. This threatens access to precision psychiatry, where diversity is crucial for innovation and equity. This Review evaluates the current state and advancements in psychiatric genomics within Latin America and the Caribbean, discusses the prevalence and burden of psychiatric disorders, explores contributions to psychiatric GWASs from these regions and highlights methods that account for genetic diversity. We also identify existing gaps and challenges and propose recommendations to promote equity in psychiatric genomics.
UR - https://www.scopus.com/pages/publications/105002137949
U2 - 10.1038/s41588-025-02127-z
DO - 10.1038/s41588-025-02127-z
M3 - Review article
C2 - 40175716
SN - 1061-4036
VL - 57
SP - 1074
EP - 1088
JO - Nature Genetics
JF - Nature Genetics
IS - 5
M1 - 6771
ER -