Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz

A. G. Markelz; A. Roitberg; E. J. Heilweil

doi:10.1016/s0009-2614(00)00227-x

Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz

A. G. Markelz
, A. Roitberg
, E. J. Heilweil

Physics

University at Buffalo

National Institute of Standards and Technology

Research output: Contribution to journal › Article › peer-review

764 Scopus citations

Abstract

We report the first use of pulsed terahertz spectroscopy to examine low-frequency collective vibrational modes of biomolecules. Broadband absorption increasing with frequency was observed for lyophilized powder samples of calf thymus DNA, bovine serum albumin and collagen in the 0.06-2.00 THz (2-67 cm^-1) frequency range, suggesting that a large number of the low-frequency collective modes for these systems are IR active. Transmission measurements at room temperature showed increasing FIR absorption with hydration and denaturing.

Original language	English
Pages (from-to)	42-48
Number of pages	7
Journal	Chemical Physics Letters
Volume	320
Issue number	1-2
DOIs	https://doi.org/10.1016/s0009-2614(00)00227-x
State	Published - Mar 31 2000

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title = "Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz",

abstract = "We report the first use of pulsed terahertz spectroscopy to examine low-frequency collective vibrational modes of biomolecules. Broadband absorption increasing with frequency was observed for lyophilized powder samples of calf thymus DNA, bovine serum albumin and collagen in the 0.06-2.00 THz (2-67 cm-1) frequency range, suggesting that a large number of the low-frequency collective modes for these systems are IR active. Transmission measurements at room temperature showed increasing FIR absorption with hydration and denaturing.",

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AU - Roitberg, A.

AU - Heilweil, E. J.

PY - 2000/3/31

Y1 - 2000/3/31

N2 - We report the first use of pulsed terahertz spectroscopy to examine low-frequency collective vibrational modes of biomolecules. Broadband absorption increasing with frequency was observed for lyophilized powder samples of calf thymus DNA, bovine serum albumin and collagen in the 0.06-2.00 THz (2-67 cm-1) frequency range, suggesting that a large number of the low-frequency collective modes for these systems are IR active. Transmission measurements at room temperature showed increasing FIR absorption with hydration and denaturing.

AB - We report the first use of pulsed terahertz spectroscopy to examine low-frequency collective vibrational modes of biomolecules. Broadband absorption increasing with frequency was observed for lyophilized powder samples of calf thymus DNA, bovine serum albumin and collagen in the 0.06-2.00 THz (2-67 cm-1) frequency range, suggesting that a large number of the low-frequency collective modes for these systems are IR active. Transmission measurements at room temperature showed increasing FIR absorption with hydration and denaturing.

UR - https://www.scopus.com/pages/publications/0001894533

U2 - 10.1016/s0009-2614(00)00227-x

DO - 10.1016/s0009-2614(00)00227-x

M3 - Article

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EP - 48

JO - Chemical Physics Letters

JF - Chemical Physics Letters

IS - 1-2

ER -

Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz

Abstract

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