Quantitative trait loci analysis of human event-related brain potentials: P3 voltage

H. Begleiter; B. Porjesz; T. Reich; H. J. Edenberg; A. Goate; J. Blangero; L. Almasy; T. Foroud; P. Van Eerdewegh; J. Polich; J. Rohrbaugh; S. Kuperman; L. O. Bauer; S. J. O'Connor; D. B. Chorlian; T. K. Li; P. M. Conneally; V. Hesselbrock; J. P. Rice; M. A. Schuckit; R. Cloninger; J. Nurnberger; R. Crowe; F. E. Bloom

doi:10.1016/S0168-5597(98)00002-1

Quantitative trait loci analysis of human event-related brain potentials: P3 voltage

H. Begleiter
, B. Porjesz
, T. Reich
, H. J. Edenberg
, A. Goate
, J. Blangero
, L. Almasy
, T. Foroud
, P. Van Eerdewegh
, J. Polich
, J. Rohrbaugh
, S. Kuperman
, L. O. Bauer
, S. J. O'Connor
, D. B. Chorlian
, T. K. Li
, P. M. Conneally
, V. Hesselbrock
, J. P. Rice
, M. A. Schuckit

R. Cloninger, J. Nurnberger, R. Crowe, F. E. Bloom

Psychiatry

SUNY Downstate Health Sciences University

SUNY Downstate Health Sciences University
Washington University St. Louis
Indiana University Bloomington
Southwest Foundation for Biomedical Research
Scripps Research Institute
University of Iowa
University of Connecticut
University of California at San Diego

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

The P3 event-related brain potential (ERP) is a positive-going voltage change of scalp-recorded electroencephalographic activity that occurs between 300-500 ms after stimulus onset. It is elicited when a stimulus is perceived, memory operations are engaged, and attentional resources are allocated toward its processing. Because this ERP component reflects fundamental cognitive processing, it has found wide utility as an assessment of human mental function in basic and clinical studies. In particular, P3 attributes are heritable and have demonstrated considerable promise as a means to identify individuals at genetic risk for alcoholism. We have conducted a quantitative linkage analysis on a large sample from families with a high density of affected individuals. The analyses suggest that several regions of the human genome contain genetic loci related to the generation of the P3 component of the ERP, which are possible candidate loci underlying the functional organization of human neuroelectric activity.

Original language	English
Pages (from-to)	244-250
Number of pages	7
Journal	Electroencephalography and Clinical Neurophysiology - Evoked Potentials
Volume	108
Issue number	3
DOIs	https://doi.org/10.1016/S0168-5597(98)00002-1
State	Published - Apr 1998

Keywords

Alcoholism
Event-related brain potentials
Heredity
P3
Quantitative trait loci

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10.1016/S0168-5597(98)00002-1

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Begleiter, H., Porjesz, B., Reich, T., Edenberg, H. J., Goate, A., Blangero, J., Almasy, L., Foroud, T., Van Eerdewegh, P., Polich, J., Rohrbaugh, J., Kuperman, S., Bauer, L. O., O'Connor, S. J., Chorlian, D. B., Li, T. K., Conneally, P. M., Hesselbrock, V., Rice, J. P., ... Bloom, F. E. (1998). Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. Electroencephalography and Clinical Neurophysiology - Evoked Potentials, 108(3), 244-250. https://doi.org/10.1016/S0168-5597(98)00002-1

@article{c863eb8a6230483cb5e7f471c49f0ae9,

title = "Quantitative trait loci analysis of human event-related brain potentials: P3 voltage",

abstract = "The P3 event-related brain potential (ERP) is a positive-going voltage change of scalp-recorded electroencephalographic activity that occurs between 300-500 ms after stimulus onset. It is elicited when a stimulus is perceived, memory operations are engaged, and attentional resources are allocated toward its processing. Because this ERP component reflects fundamental cognitive processing, it has found wide utility as an assessment of human mental function in basic and clinical studies. In particular, P3 attributes are heritable and have demonstrated considerable promise as a means to identify individuals at genetic risk for alcoholism. We have conducted a quantitative linkage analysis on a large sample from families with a high density of affected individuals. The analyses suggest that several regions of the human genome contain genetic loci related to the generation of the P3 component of the ERP, which are possible candidate loci underlying the functional organization of human neuroelectric activity.",

keywords = "Alcoholism, Event-related brain potentials, Heredity, P3, Quantitative trait loci",

author = "H. Begleiter and B. Porjesz and T. Reich and Edenberg, \{H. J.\} and A. Goate and J. Blangero and L. Almasy and T. Foroud and \{Van Eerdewegh\}, P. and J. Polich and J. Rohrbaugh and S. Kuperman and Bauer, \{L. O.\} and O'Connor, \{S. J.\} and Chorlian, \{D. B.\} and Li, \{T. K.\} and Conneally, \{P. M.\} and V. Hesselbrock and Rice, \{J. P.\} and Schuckit, \{M. A.\} and R. Cloninger and J. Nurnberger and R. Crowe and Bloom, \{F. E.\}",

year = "1998",

month = apr,

doi = "10.1016/S0168-5597(98)00002-1",

language = "English",

volume = "108",

pages = "244--250",

journal = "Electroencephalography and Clinical Neurophysiology - Evoked Potentials",

issn = "0168-5597",

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number = "3",

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Begleiter, H, Porjesz, B, Reich, T, Edenberg, HJ, Goate, A, Blangero, J, Almasy, L, Foroud, T, Van Eerdewegh, P, Polich, J, Rohrbaugh, J, Kuperman, S, Bauer, LO, O'Connor, SJ, Chorlian, DB, Li, TK, Conneally, PM, Hesselbrock, V, Rice, JP, Schuckit, MA, Cloninger, R, Nurnberger, J, Crowe, R & Bloom, FE 1998, 'Quantitative trait loci analysis of human event-related brain potentials: P3 voltage', Electroencephalography and Clinical Neurophysiology - Evoked Potentials, vol. 108, no. 3, pp. 244-250. https://doi.org/10.1016/S0168-5597(98)00002-1

TY - JOUR

T1 - Quantitative trait loci analysis of human event-related brain potentials

T2 - P3 voltage

AU - Begleiter, H.

AU - Porjesz, B.

AU - Reich, T.

AU - Edenberg, H. J.

AU - Goate, A.

AU - Blangero, J.

AU - Almasy, L.

AU - Foroud, T.

AU - Van Eerdewegh, P.

AU - Polich, J.

AU - Rohrbaugh, J.

AU - Kuperman, S.

AU - Bauer, L. O.

AU - O'Connor, S. J.

AU - Chorlian, D. B.

AU - Li, T. K.

AU - Conneally, P. M.

AU - Hesselbrock, V.

AU - Rice, J. P.

AU - Schuckit, M. A.

AU - Cloninger, R.

AU - Nurnberger, J.

AU - Crowe, R.

AU - Bloom, F. E.

PY - 1998/4

Y1 - 1998/4

N2 - The P3 event-related brain potential (ERP) is a positive-going voltage change of scalp-recorded electroencephalographic activity that occurs between 300-500 ms after stimulus onset. It is elicited when a stimulus is perceived, memory operations are engaged, and attentional resources are allocated toward its processing. Because this ERP component reflects fundamental cognitive processing, it has found wide utility as an assessment of human mental function in basic and clinical studies. In particular, P3 attributes are heritable and have demonstrated considerable promise as a means to identify individuals at genetic risk for alcoholism. We have conducted a quantitative linkage analysis on a large sample from families with a high density of affected individuals. The analyses suggest that several regions of the human genome contain genetic loci related to the generation of the P3 component of the ERP, which are possible candidate loci underlying the functional organization of human neuroelectric activity.

AB - The P3 event-related brain potential (ERP) is a positive-going voltage change of scalp-recorded electroencephalographic activity that occurs between 300-500 ms after stimulus onset. It is elicited when a stimulus is perceived, memory operations are engaged, and attentional resources are allocated toward its processing. Because this ERP component reflects fundamental cognitive processing, it has found wide utility as an assessment of human mental function in basic and clinical studies. In particular, P3 attributes are heritable and have demonstrated considerable promise as a means to identify individuals at genetic risk for alcoholism. We have conducted a quantitative linkage analysis on a large sample from families with a high density of affected individuals. The analyses suggest that several regions of the human genome contain genetic loci related to the generation of the P3 component of the ERP, which are possible candidate loci underlying the functional organization of human neuroelectric activity.

KW - Alcoholism

KW - Event-related brain potentials

KW - Heredity

KW - P3

KW - Quantitative trait loci

UR - https://www.scopus.com/pages/publications/0031809736

U2 - 10.1016/S0168-5597(98)00002-1

DO - 10.1016/S0168-5597(98)00002-1

M3 - Article

C2 - 9607513

SN - 0168-5597

VL - 108

SP - 244

EP - 250

JO - Electroencephalography and Clinical Neurophysiology - Evoked Potentials

JF - Electroencephalography and Clinical Neurophysiology - Evoked Potentials

IS - 3

ER -

Quantitative trait loci analysis of human event-related brain potentials: P3 voltage

Abstract

Keywords

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