RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging

P. Vaska; C. L. Woody; D. J. Schlyer; S. Shokouhi; S. P. Stoll; J. F. Pratte; P. O'Connon; S. S. Junnarkar; S. Rescia; B. Yu; M. Purschke; A. Kandasamy; A. Villanueva; A. Kriplani; V. Radeka; N. Volkow; R. Lecomte; R. Fontaine

doi:10.1109/nssmic.2003.1352223

RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging

P. Vaska
, C. L. Woody
, D. J. Schlyer
, S. Shokouhi
, S. P. Stoll
, J. F. Pratte
, P. O'Connon
, S. S. Junnarkar
, S. Rescia
, B. Yu
, M. Purschke
, A. Kandasamy
, A. Villanueva
, A. Kriplani
, V. Radeka
, N. Volkow
, R. Lecomte
, R. Fontaine

Dept of Biomedical Engineering

Stony Brook University

Research output: Contribution to journal › Conference article › peer-review

5 Scopus citations

Abstract

Anesthesia is currently required for PET studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects the neurological state of the animal, complicating the interpretation of PET results. Furthermore, it precludes the use of PET to study the brain during natural behavior. The RatCAP tomograph (Rat Conscious Animal PET) is designed to eliminate the need for anesthesia in rat brain studies. It is a miniaturized full-ring PET scanner which is attached directly to the head, covering nearly the entire brain. RatCAP utilizes arrays of 2 mm × 2 mm LSO crystals coupled to matching avalanche photodiode arrays, which are in turn read out by full custom integrated circuits. Principal challenges have been addressed considering the physical constraints on size, weight, and heat generation in addition to the usual requirements of small-animal PET such as high spatial resolution in the presence of parallax error. A partial prototype has been constructed and preliminary measurements and optimization completed. Realistic Monte Carlo simulations have also been carried out to optimize system performance, which is predicted to be competitive with existing microPET systems.

Original language	English
Article number	M3-7
Pages (from-to)	1780-1784
Number of pages	5
Journal	IEEE Nuclear Science Symposium Conference Record
Volume	3
DOIs	https://doi.org/10.1109/nssmic.2003.1352223
State	Published - 2003
Event	2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference - Portland, OR, United States Duration: Oct 19 2003 → Oct 25 2003

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Vaska, P., Woody, C. L., Schlyer, D. J., Shokouhi, S., Stoll, S. P., Pratte, J. F., O'Connon, P., Junnarkar, S. S., Rescia, S., Yu, B., Purschke, M., Kandasamy, A., Villanueva, A., Kriplani, A., Radeka, V., Volkow, N., Lecomte, R., & Fontaine, R. (2003). RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging. IEEE Nuclear Science Symposium Conference Record, 3, 1780-1784. Article M3-7. https://doi.org/10.1109/nssmic.2003.1352223

@article{f0a0944d0ba74fc796b25533ff6f2145,

title = "RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging",

abstract = "Anesthesia is currently required for PET studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects the neurological state of the animal, complicating the interpretation of PET results. Furthermore, it precludes the use of PET to study the brain during natural behavior. The RatCAP tomograph (Rat Conscious Animal PET) is designed to eliminate the need for anesthesia in rat brain studies. It is a miniaturized full-ring PET scanner which is attached directly to the head, covering nearly the entire brain. RatCAP utilizes arrays of 2 mm × 2 mm LSO crystals coupled to matching avalanche photodiode arrays, which are in turn read out by full custom integrated circuits. Principal challenges have been addressed considering the physical constraints on size, weight, and heat generation in addition to the usual requirements of small-animal PET such as high spatial resolution in the presence of parallax error. A partial prototype has been constructed and preliminary measurements and optimization completed. Realistic Monte Carlo simulations have also been carried out to optimize system performance, which is predicted to be competitive with existing microPET systems.",

author = "P. Vaska and Woody, \{C. L.\} and Schlyer, \{D. J.\} and S. Shokouhi and Stoll, \{S. P.\} and Pratte, \{J. F.\} and P. O'Connon and Junnarkar, \{S. S.\} and S. Rescia and B. Yu and M. Purschke and A. Kandasamy and A. Villanueva and A. Kriplani and V. Radeka and N. Volkow and R. Lecomte and R. Fontaine",

year = "2003",

doi = "10.1109/nssmic.2003.1352223",

language = "English",

volume = "3",

pages = "1780--1784",

journal = "IEEE Nuclear Science Symposium Conference Record",

issn = "1095-7863",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference ; Conference date: 19-10-2003 Through 25-10-2003",

}

Vaska, P, Woody, CL, Schlyer, DJ, Shokouhi, S, Stoll, SP, Pratte, JF, O'Connon, P, Junnarkar, SS, Rescia, S, Yu, B, Purschke, M, Kandasamy, A, Villanueva, A, Kriplani, A, Radeka, V, Volkow, N, Lecomte, R & Fontaine, R 2003, 'RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging', IEEE Nuclear Science Symposium Conference Record, vol. 3, M3-7, pp. 1780-1784. https://doi.org/10.1109/nssmic.2003.1352223

TY - JOUR

T1 - RatCAP

T2 - 2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference

AU - Vaska, P.

AU - Woody, C. L.

AU - Schlyer, D. J.

AU - Shokouhi, S.

AU - Stoll, S. P.

AU - Pratte, J. F.

AU - O'Connon, P.

AU - Junnarkar, S. S.

AU - Rescia, S.

AU - Yu, B.

AU - Purschke, M.

AU - Kandasamy, A.

AU - Villanueva, A.

AU - Kriplani, A.

AU - Radeka, V.

AU - Volkow, N.

AU - Lecomte, R.

AU - Fontaine, R.

PY - 2003

Y1 - 2003

N2 - Anesthesia is currently required for PET studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects the neurological state of the animal, complicating the interpretation of PET results. Furthermore, it precludes the use of PET to study the brain during natural behavior. The RatCAP tomograph (Rat Conscious Animal PET) is designed to eliminate the need for anesthesia in rat brain studies. It is a miniaturized full-ring PET scanner which is attached directly to the head, covering nearly the entire brain. RatCAP utilizes arrays of 2 mm × 2 mm LSO crystals coupled to matching avalanche photodiode arrays, which are in turn read out by full custom integrated circuits. Principal challenges have been addressed considering the physical constraints on size, weight, and heat generation in addition to the usual requirements of small-animal PET such as high spatial resolution in the presence of parallax error. A partial prototype has been constructed and preliminary measurements and optimization completed. Realistic Monte Carlo simulations have also been carried out to optimize system performance, which is predicted to be competitive with existing microPET systems.

AB - Anesthesia is currently required for PET studies of the animal brain in order to eliminate motion artifacts. However, anesthesia profoundly affects the neurological state of the animal, complicating the interpretation of PET results. Furthermore, it precludes the use of PET to study the brain during natural behavior. The RatCAP tomograph (Rat Conscious Animal PET) is designed to eliminate the need for anesthesia in rat brain studies. It is a miniaturized full-ring PET scanner which is attached directly to the head, covering nearly the entire brain. RatCAP utilizes arrays of 2 mm × 2 mm LSO crystals coupled to matching avalanche photodiode arrays, which are in turn read out by full custom integrated circuits. Principal challenges have been addressed considering the physical constraints on size, weight, and heat generation in addition to the usual requirements of small-animal PET such as high spatial resolution in the presence of parallax error. A partial prototype has been constructed and preliminary measurements and optimization completed. Realistic Monte Carlo simulations have also been carried out to optimize system performance, which is predicted to be competitive with existing microPET systems.

UR - https://www.scopus.com/pages/publications/19944428512

U2 - 10.1109/nssmic.2003.1352223

DO - 10.1109/nssmic.2003.1352223

M3 - Conference article

SN - 1095-7863

VL - 3

SP - 1780

EP - 1784

JO - IEEE Nuclear Science Symposium Conference Record

JF - IEEE Nuclear Science Symposium Conference Record

M1 - M3-7

Y2 - 19 October 2003 through 25 October 2003

ER -

RatCAP: Miniaturized head-mounted PET for conscious rodent brain imaging

Abstract

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