Recombinant interleukin-1 stimulates prostaglandin E2 production by osteoblastic cells: Synergy with parathyroid hormone

Dimitris N. Tatakis; Gerald Schneeberger; Rosemary Dziak

doi:10.1007/BF02556353

Recombinant interleukin-1 stimulates prostaglandin E₂ production by osteoblastic cells: Synergy with parathyroid hormone

Dimitris N. Tatakis
, Gerald Schneeberger
, Rosemary Dziak

Department of Oral Biology

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Recombinant mouse IL-1 (Interleukin-1) has been shown to be capable of stimulating prostaglandin E₂ (PGE₂) production by isolated rat osteoblastic cells in a dose-dependent manner. The rapidity of the effect (1 hour) and the potency of IL-1 (5×10^-12 M) in producing this effect suggest that IL-1 may exert some of its effects on bone via PGE₂. Parathyroid hormone (PTH) appears to have a strong synergistic effect with IL-1. These data further substantiate the role of IL-1 in bone physiology.

Original language	English
Pages (from-to)	358-362
Number of pages	5
Journal	Calcified tissue international
Volume	42
Issue number	6
DOIs	https://doi.org/10.1007/BF02556353
State	Published - Nov 1988

Keywords

Interleukin-1
Osteoblast
Parathyroid hormone
Prostaglandin

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10.1007/BF02556353

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title = "Recombinant interleukin-1 stimulates prostaglandin E2 production by osteoblastic cells: Synergy with parathyroid hormone",

abstract = "Recombinant mouse IL-1 (Interleukin-1) has been shown to be capable of stimulating prostaglandin E2 (PGE2) production by isolated rat osteoblastic cells in a dose-dependent manner. The rapidity of the effect (1 hour) and the potency of IL-1 (5×10-12 M) in producing this effect suggest that IL-1 may exert some of its effects on bone via PGE2. Parathyroid hormone (PTH) appears to have a strong synergistic effect with IL-1. These data further substantiate the role of IL-1 in bone physiology.",

keywords = "Interleukin-1, Osteoblast, Parathyroid hormone, Prostaglandin",

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doi = "10.1007/BF02556353",

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T1 - Recombinant interleukin-1 stimulates prostaglandin E2 production by osteoblastic cells

T2 - Synergy with parathyroid hormone

AU - Tatakis, Dimitris N.

AU - Schneeberger, Gerald

AU - Dziak, Rosemary

PY - 1988/11

Y1 - 1988/11

N2 - Recombinant mouse IL-1 (Interleukin-1) has been shown to be capable of stimulating prostaglandin E2 (PGE2) production by isolated rat osteoblastic cells in a dose-dependent manner. The rapidity of the effect (1 hour) and the potency of IL-1 (5×10-12 M) in producing this effect suggest that IL-1 may exert some of its effects on bone via PGE2. Parathyroid hormone (PTH) appears to have a strong synergistic effect with IL-1. These data further substantiate the role of IL-1 in bone physiology.

AB - Recombinant mouse IL-1 (Interleukin-1) has been shown to be capable of stimulating prostaglandin E2 (PGE2) production by isolated rat osteoblastic cells in a dose-dependent manner. The rapidity of the effect (1 hour) and the potency of IL-1 (5×10-12 M) in producing this effect suggest that IL-1 may exert some of its effects on bone via PGE2. Parathyroid hormone (PTH) appears to have a strong synergistic effect with IL-1. These data further substantiate the role of IL-1 in bone physiology.

KW - Interleukin-1

KW - Osteoblast

KW - Parathyroid hormone

KW - Prostaglandin

UR - https://www.scopus.com/pages/publications/0023876874

U2 - 10.1007/BF02556353

DO - 10.1007/BF02556353

M3 - Article

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SN - 0171-967X

VL - 42

SP - 358

EP - 362

JO - Calcified tissue international

JF - Calcified tissue international

IS - 6

ER -

Recombinant interleukin-1 stimulates prostaglandin E₂ production by osteoblastic cells: Synergy with parathyroid hormone

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Keywords

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