Abstract
Microvascular pathology appears to be a major component of the pathophysiology of Behcet's disease. The purpose of this study was to determine red-cell membrane fluidity-deformability in patients with Behcet's disease, a factor known to involve microvascular circulation. The red-cell Alteration test of deformability of Reid et al (Reid, et al, 1976a and 1976b) was employed. The study was undertaken due to an observation of a case that is described in detail. Fifteen additional patients were studied and all were found to have decreased red-cell membrane fluidity-increased red-cell "stiffness". It was thought that increased red-cell rigidity may contribute to microvascular and thromboembolic phenomena in patients with Behcet's disease.
| Original language | English |
|---|---|
| Pages (from-to) | 61-68 |
| Number of pages | 8 |
| Journal | Journal of Medicine |
| Volume | 36 |
| Issue number | 1-6 |
| State | Published - 2005 |
Keywords
- Ankylosing spondilitis
- Behcet's disease
- Homocysteinemia red-cell membrane fluidity
- Red-cell stiffness
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