Relationship of dose- and time-dependent corticosteroid responses to receptor turnover

William J. Jusko

doi:10.3109/9780203908532-7

Relationship of dose- and time-dependent corticosteroid responses to receptor turnover

William J. Jusko

Pharmaceutical Sciences

University at Buffalo

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Dr. Brattsand: We have studied how RU486 affects the cytokine blocking ef?cacy of the b2-agonist formoterol in a bronchial epithelial cell model. While RU fully blocks the anticytokine effects off budesonide, it does not at all counteract the cytokine-modulating activity of formeterol. This suggests that the cytokine-modulating effect of b2-agonists is not mediated by the GC receptor in these cells.

Original language	English
Title of host publication	Inhaled Steroids in Asthma
Subtitle of host publication	Optimizing Effects in the Airways
Publisher	CRC Press
Pages	95-112
Number of pages	18
ISBN (Electronic)	9780203908532
ISBN (Print)	9780824705855
DOIs	https://doi.org/10.3109/9780203908532-7
State	Published - Jan 1 2016

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10.3109/9780203908532-7

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title = "Relationship of dose- and time-dependent corticosteroid responses to receptor turnover",

abstract = "Dr. Brattsand: We have studied how RU486 affects the cytokine blocking ef?cacy of the b2-agonist formoterol in a bronchial epithelial cell model. While RU fully blocks the anticytokine effects off budesonide, it does not at all counteract the cytokine-modulating activity of formeterol. This suggests that the cytokine-modulating effect of b2-agonists is not mediated by the GC receptor in these cells.",

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AB - Dr. Brattsand: We have studied how RU486 affects the cytokine blocking ef?cacy of the b2-agonist formoterol in a bronchial epithelial cell model. While RU fully blocks the anticytokine effects off budesonide, it does not at all counteract the cytokine-modulating activity of formeterol. This suggests that the cytokine-modulating effect of b2-agonists is not mediated by the GC receptor in these cells.

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Relationship of dose- and time-dependent corticosteroid responses to receptor turnover

Abstract

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