Abstract
We report here the first demonstration of dengue virus infection and vasoactive cytokine response of a cell of the mast cell/basophil lineage. Infection of KU812 cells was dependent on dengue-specific antibody and gave rise to infectious virions. This antibody-enhanced dengue virus infection triggered a four- to fivefold increase in the release of interleukin-1β (IL- 1β) and a modest increase for IL-6 but not for an alternate cytokine, granulocyte-macrophage colony-stimulating factor. The results suggest a potential role for mast cells/basophils in the pathogenesis of dengue virus- induced disease.
| Original language | English |
|---|---|
| Pages (from-to) | 7146-7150 |
| Number of pages | 5 |
| Journal | Journal of Virology |
| Volume | 74 |
| Issue number | 15 |
| DOIs | |
| State | Published - Aug 2000 |
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