Resistance of W/Fu Rats to Adrenal Regeneration Hypertension

The procedure for producing adrenal regeneration hypertension did not cause an increase in the systolic blood pressure of W/Fu animals. The regenerating adrenal gland in W/Fu animals was not restored to normal; reduced numbers of mitochondrial cristae were seen and the mitochondria were smaller in size; regeneration was complete in Sprague-Dawley rats of the Holtzman strain and there was a severe form of hypertensive, cardiovascular disease. The authors are grateful to Mrs. Yam Pun, Mrs. Neonile Fylypiw, Mr. Luther Joseph, Mrs. Geneva Joseph, Mrs. Elisabeth Lawson, and Mr. Robert Linsmair for skilled technical assistance.