Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals

Eunice Y. Yuen; Ping Zhong; Xiangning Li; Jing Wei; Zhen Yan

doi:10.1074/jbc.M112.396648

Restoration of glutamatergic transmission by dopamine D₄ receptors in stressed animals

Eunice Y. Yuen
, Ping Zhong
, Xiangning Li
, Jing Wei
, Zhen Yan

Physiology and Biophysics

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Background: The dopamine D4 receptors in prefrontal cortex (PFC) play a key role in mental health and disorders. Results: D4 activation caused a bi-directional, homeostatic regulation of glutamatergic responses in rats exposed to acute or chronic stress. Conclusion: The altered synaptic excitation in stress conditions is restored by D4 signaling in PFC. Significance: It provides a potential mechanism for the role of D4 in stress-related neuropsychiatric disorders.

Original language	English
Pages (from-to)	26112-26120
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M112.396648
State	Published - Sep 6 2013

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10.1074/jbc.M112.396648

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title = "Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals",

abstract = "Background: The dopamine D4 receptors in prefrontal cortex (PFC) play a key role in mental health and disorders. Results: D4 activation caused a bi-directional, homeostatic regulation of glutamatergic responses in rats exposed to acute or chronic stress. Conclusion: The altered synaptic excitation in stress conditions is restored by D4 signaling in PFC. Significance: It provides a potential mechanism for the role of D4 in stress-related neuropsychiatric disorders.",

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AU - Yuen, Eunice Y.

AU - Zhong, Ping

AU - Li, Xiangning

AU - Wei, Jing

AU - Yan, Zhen

PY - 2013/9/6

Y1 - 2013/9/6

N2 - Background: The dopamine D4 receptors in prefrontal cortex (PFC) play a key role in mental health and disorders. Results: D4 activation caused a bi-directional, homeostatic regulation of glutamatergic responses in rats exposed to acute or chronic stress. Conclusion: The altered synaptic excitation in stress conditions is restored by D4 signaling in PFC. Significance: It provides a potential mechanism for the role of D4 in stress-related neuropsychiatric disorders.

AB - Background: The dopamine D4 receptors in prefrontal cortex (PFC) play a key role in mental health and disorders. Results: D4 activation caused a bi-directional, homeostatic regulation of glutamatergic responses in rats exposed to acute or chronic stress. Conclusion: The altered synaptic excitation in stress conditions is restored by D4 signaling in PFC. Significance: It provides a potential mechanism for the role of D4 in stress-related neuropsychiatric disorders.

UR - https://www.scopus.com/pages/publications/84883697808

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DO - 10.1074/jbc.M112.396648

M3 - Article

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VL - 288

SP - 26112

EP - 26120

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ER -

Restoration of glutamatergic transmission by dopamine D₄ receptors in stressed animals

Abstract

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