Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1

Pauline Mendola; Kirsten B. Moysich; Jo L. Freudenheim; Peter G. Shields; Enrique F. Schisterman; Saxon Graham; John E. Vena; James R. Marshall; Christine B. Ambrosone

doi:10.1097/00001648-199811000-00018

Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1

Pauline Mendola
, Kirsten B. Moysich
, Jo L. Freudenheim
, Peter G. Shields
, Enrique F. Schisterman
, Saxon Graham
, John E. Vena
, James R. Marshall
, Christine B. Ambrosone

Department of Epidemiology and Environmental Health

University at Buffalo

National Institutes of Health
SUNY Buffalo
United States Food and Drug Administration

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.

Original language	English
Pages (from-to)	666-668
Number of pages	3
Journal	Epidemiology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1097/00001648-199811000-00018
State	Published - Nov 1998

Keywords

Gene-environment interaction
Genetic polymorphism
Glutathione S-transferase M1
Molecular epidemiology
N-acetyltransferase 2
Spontaneous abortion

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10.1097/00001648-199811000-00018

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title = "Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1",

abstract = "Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95\% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.",

keywords = "Gene-environment interaction, Genetic polymorphism, Glutathione S-transferase M1, Molecular epidemiology, N-acetyltransferase 2, Spontaneous abortion",

author = "Pauline Mendola and Moysich, \{Kirsten B.\} and Freudenheim, \{Jo L.\} and Shields, \{Peter G.\} and Schisterman, \{Enrique F.\} and Saxon Graham and Vena, \{John E.\} and Marshall, \{James R.\} and Ambrosone, \{Christine B.\}",

year = "1998",

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doi = "10.1097/00001648-199811000-00018",

language = "English",

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pages = "666--668",

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TY - JOUR

T1 - Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1

AU - Mendola, Pauline

AU - Moysich, Kirsten B.

AU - Freudenheim, Jo L.

AU - Shields, Peter G.

AU - Schisterman, Enrique F.

AU - Graham, Saxon

AU - Vena, John E.

AU - Marshall, James R.

AU - Ambrosone, Christine B.

PY - 1998/11

Y1 - 1998/11

N2 - Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.

AB - Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.

KW - Gene-environment interaction

KW - Genetic polymorphism

KW - Glutathione S-transferase M1

KW - Molecular epidemiology

KW - N-acetyltransferase 2

KW - Spontaneous abortion

UR - https://www.scopus.com/pages/publications/0031717327

U2 - 10.1097/00001648-199811000-00018

DO - 10.1097/00001648-199811000-00018

M3 - Article

C2 - 9799179

SN - 1044-3983

VL - 9

SP - 666

EP - 668

JO - Epidemiology

JF - Epidemiology

IS - 6

ER -

Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1

Abstract

Keywords

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