Salsolinol differentially affects mice selected for sensitivity to alcohol

A. C. Church; J. L. Fuller; B. C. Dudek

doi:10.1007/BF00428700

Salsolinol differentially affects mice selected for sensitivity to alcohol

A. C. Church
, J. L. Fuller
, B. C. Dudek

Psychology

University at Albany

State University of New York Binghamton University

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Salsolinol, a compound putatively formed following alcohol ingestion, differentially decreased the activity of lines of mice after 18 generations of genetic selection for alcohol sensitivity. Low doses of salsolinol produced significantly lower activity levels in the alcohol-sensitive long-sleep (LS) line than in the alcohol-insensitive short-sleep (SS) line. A hypnotic dose of salsolinol induced significantly longer sleep-times in the LS line than in the SS line. Results are interpreted as supporting the hypothesis that salsolinol-like substances may mediate some of the effects of alcohol on the central nervous system.

Original language	English
Pages (from-to)	49-52
Number of pages	4
Journal	Psychopharmacology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1007/BF00428700
State	Published - Jan 1976

Keywords

Behavior genetics
Ethanol narcosis
Intracisternal
Locomotor activity
Salsolinol
Selected lines

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10.1007/BF00428700

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title = "Salsolinol differentially affects mice selected for sensitivity to alcohol",

abstract = "Salsolinol, a compound putatively formed following alcohol ingestion, differentially decreased the activity of lines of mice after 18 generations of genetic selection for alcohol sensitivity. Low doses of salsolinol produced significantly lower activity levels in the alcohol-sensitive long-sleep (LS) line than in the alcohol-insensitive short-sleep (SS) line. A hypnotic dose of salsolinol induced significantly longer sleep-times in the LS line than in the SS line. Results are interpreted as supporting the hypothesis that salsolinol-like substances may mediate some of the effects of alcohol on the central nervous system.",

keywords = "Behavior genetics, Ethanol narcosis, Intracisternal, Locomotor activity, Salsolinol, Selected lines",

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year = "1976",

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AU - Church, A. C.

AU - Fuller, J. L.

AU - Dudek, B. C.

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N2 - Salsolinol, a compound putatively formed following alcohol ingestion, differentially decreased the activity of lines of mice after 18 generations of genetic selection for alcohol sensitivity. Low doses of salsolinol produced significantly lower activity levels in the alcohol-sensitive long-sleep (LS) line than in the alcohol-insensitive short-sleep (SS) line. A hypnotic dose of salsolinol induced significantly longer sleep-times in the LS line than in the SS line. Results are interpreted as supporting the hypothesis that salsolinol-like substances may mediate some of the effects of alcohol on the central nervous system.

AB - Salsolinol, a compound putatively formed following alcohol ingestion, differentially decreased the activity of lines of mice after 18 generations of genetic selection for alcohol sensitivity. Low doses of salsolinol produced significantly lower activity levels in the alcohol-sensitive long-sleep (LS) line than in the alcohol-insensitive short-sleep (SS) line. A hypnotic dose of salsolinol induced significantly longer sleep-times in the LS line than in the SS line. Results are interpreted as supporting the hypothesis that salsolinol-like substances may mediate some of the effects of alcohol on the central nervous system.

KW - Behavior genetics

KW - Ethanol narcosis

KW - Intracisternal

KW - Locomotor activity

KW - Salsolinol

KW - Selected lines

UR - https://www.scopus.com/pages/publications/0017124968

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DO - 10.1007/BF00428700

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VL - 47

SP - 49

EP - 52

JO - Psychopharmacology

JF - Psychopharmacology

IS - 1

ER -

Salsolinol differentially affects mice selected for sensitivity to alcohol

Abstract

Keywords

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