Self-assembly of cationic, hetero- or homonuclear ruthenium(II) macrocyclic rectangles and their photophysical, electrochemical, and biological studies

Vaishali Vajpayee; Young Ho Song; Yoon Jung Yang; Se Chan Kang; Timothy R. Cook; Dong Wook Kim; Myoung Soo Lah; In Su Kim; Ming Wang; Peter J. Stang; Ki Whan Chi

doi:10.1021/om200908c

Self-assembly of cationic, hetero- or homonuclear ruthenium(II) macrocyclic rectangles and their photophysical, electrochemical, and biological studies

Vaishali Vajpayee
, Young Ho Song
, Yoon Jung Yang
, Se Chan Kang
, Timothy R. Cook
, Dong Wook Kim
, Myoung Soo Lah
, In Su Kim
, Ming Wang
, Peter J. Stang
, Ki Whan Chi

Chemistry

University at Buffalo

University of Ulsan
University of Semyung
Ulsan National Institute of Science and Technology
University of Utah

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

A series of supramolecular rectangles, including two mixed-metal Ru/Pt complexes, have been formed by the coordination-driven self-assembly of a range of arene-Ru "molecular clip" acceptors (1a-1d) with rigid dipyridyl-based ligands (2a-2d) over the course of 10 h in solution. The isolated products were characterized by multinuclear NMR (¹H and ¹³C or ³¹P), HR-ESI-MS, and an X-ray diffraction study to support the ascribed two-component rectangular structures. The rectangles were further characterized by UV-vis and fluorescence studies. The redox behaviors of rectangles 3ca and 3da were also determined using cyclic voltammetry. Additionally, the antitumor activities of the suite of rectangles were determined against various human cancer cell lines, and significant activity was shown by complexes 3ca, 3da, 3cb, 3cc, and 3cd, with IC₅₀ values as low as 2.65 μM.

Original language	English
Pages (from-to)	6482-6489
Number of pages	8
Journal	Organometallics
Volume	30
Issue number	23
DOIs	https://doi.org/10.1021/om200908c
State	Published - Dec 12 2011

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@article{66ae31b3d6124cd3a9bd995625ddd7b7,

title = "Self-assembly of cationic, hetero- or homonuclear ruthenium(II) macrocyclic rectangles and their photophysical, electrochemical, and biological studies",

abstract = "A series of supramolecular rectangles, including two mixed-metal Ru/Pt complexes, have been formed by the coordination-driven self-assembly of a range of arene-Ru {"}molecular clip{"} acceptors (1a-1d) with rigid dipyridyl-based ligands (2a-2d) over the course of 10 h in solution. The isolated products were characterized by multinuclear NMR (1H and 13C or 31P), HR-ESI-MS, and an X-ray diffraction study to support the ascribed two-component rectangular structures. The rectangles were further characterized by UV-vis and fluorescence studies. The redox behaviors of rectangles 3ca and 3da were also determined using cyclic voltammetry. Additionally, the antitumor activities of the suite of rectangles were determined against various human cancer cell lines, and significant activity was shown by complexes 3ca, 3da, 3cb, 3cc, and 3cd, with IC50 values as low as 2.65 μM.",

author = "Vaishali Vajpayee and Song, \{Young Ho\} and Yang, \{Yoon Jung\} and Kang, \{Se Chan\} and Cook, \{Timothy R.\} and Kim, \{Dong Wook\} and Lah, \{Myoung Soo\} and Kim, \{In Su\} and Ming Wang and Stang, \{Peter J.\} and Chi, \{Ki Whan\}",

year = "2011",

month = dec,

day = "12",

doi = "10.1021/om200908c",

language = "English",

volume = "30",

pages = "6482--6489",

journal = "Organometallics",

issn = "0276-7333",

publisher = "American Chemical Society",

number = "23",

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TY - JOUR

T1 - Self-assembly of cationic, hetero- or homonuclear ruthenium(II) macrocyclic rectangles and their photophysical, electrochemical, and biological studies

AU - Vajpayee, Vaishali

AU - Song, Young Ho

AU - Yang, Yoon Jung

AU - Kang, Se Chan

AU - Cook, Timothy R.

AU - Kim, Dong Wook

AU - Lah, Myoung Soo

AU - Kim, In Su

AU - Wang, Ming

AU - Stang, Peter J.

AU - Chi, Ki Whan

PY - 2011/12/12

Y1 - 2011/12/12

N2 - A series of supramolecular rectangles, including two mixed-metal Ru/Pt complexes, have been formed by the coordination-driven self-assembly of a range of arene-Ru "molecular clip" acceptors (1a-1d) with rigid dipyridyl-based ligands (2a-2d) over the course of 10 h in solution. The isolated products were characterized by multinuclear NMR (1H and 13C or 31P), HR-ESI-MS, and an X-ray diffraction study to support the ascribed two-component rectangular structures. The rectangles were further characterized by UV-vis and fluorescence studies. The redox behaviors of rectangles 3ca and 3da were also determined using cyclic voltammetry. Additionally, the antitumor activities of the suite of rectangles were determined against various human cancer cell lines, and significant activity was shown by complexes 3ca, 3da, 3cb, 3cc, and 3cd, with IC50 values as low as 2.65 μM.

AB - A series of supramolecular rectangles, including two mixed-metal Ru/Pt complexes, have been formed by the coordination-driven self-assembly of a range of arene-Ru "molecular clip" acceptors (1a-1d) with rigid dipyridyl-based ligands (2a-2d) over the course of 10 h in solution. The isolated products were characterized by multinuclear NMR (1H and 13C or 31P), HR-ESI-MS, and an X-ray diffraction study to support the ascribed two-component rectangular structures. The rectangles were further characterized by UV-vis and fluorescence studies. The redox behaviors of rectangles 3ca and 3da were also determined using cyclic voltammetry. Additionally, the antitumor activities of the suite of rectangles were determined against various human cancer cell lines, and significant activity was shown by complexes 3ca, 3da, 3cb, 3cc, and 3cd, with IC50 values as low as 2.65 μM.

UR - https://www.scopus.com/pages/publications/82955169691

U2 - 10.1021/om200908c

DO - 10.1021/om200908c

M3 - Article

SN - 0276-7333

VL - 30

SP - 6482

EP - 6489

JO - Organometallics

JF - Organometallics

IS - 23

ER -

Self-assembly of cationic, hetero- or homonuclear ruthenium(II) macrocyclic rectangles and their photophysical, electrochemical, and biological studies

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